Laura L. Kiessling Explained

Laura Kiessling
Birth Name:Laura Lee Kiessling
Birth Date:21 September 1960
Birth Place:Lake Mills, Wisconsin
Nationality:American
Field:Chemical Biology
Workplaces:University of Wisconsin–Madison
Massachusetts Institute of Technology
Education:Massachusetts Institute of Technology
Yale University
Doctoral Students:Samira Musah
Known For:Research on multivalent protein-carbohydrate interactions; carbohydrate polymers

Laura Lee Kiessling (born 21 September 1960) is an American chemist and the Novartis Professor of Chemistry at the Massachusetts Institute of Technology.[1] Kiessling's research focuses on elucidating and exploiting interactions on the cell surface, especially those mediated by proteins binding to carbohydrates. Multivalent protein-carbohydrate interactions play roles in cell-cell recognition and signal transduction. Understanding and manipulating these interactions provides tools to study biological processes and design therapeutic treatments. Kiessling's interdisciplinary research combines organic synthesis, polymer chemistry, structural biology, and molecular and cell biology.[2] [3]

Education

Kiessling earned a B.S. in chemistry from the Massachusetts Institute of Technology in 1983 and a Ph.D. in chemistry from Yale University in 1989.[4] At Yale, she worked with Stuart Schreiber to synthesize and study small molecules as probes of biological function. After earning her PhD, Kiessling spent two years at the California Institute of Technology as an American Cancer Society Postdoctoral Fellow, where she worked with Peter B. Dervan to study DNA recognition and cleavage.

Career

In 1991, Kiessling joined the faculty of the University of Wisconsin–Madison,[5] where she became the Steenbock Professor of Chemistry and the Laurens Anderson Professor of Biochemistry. While at UW-Madison, Kiessling also became the director of the Keck Center for Chemical Genomics[6] and the National Institutes of Health Chemistry-Biology Interface Training Program.[7] In 2017, she moved to the Massachusetts Institute of Technology as the Novartis Professor of Chemistry.[8] as well as the editor-in-chief of ACS Chemical Biology.[9] [10] [11]

Kiessling's contributions span the fields of organic synthesis, polymer chemistry, and molecular biology. She has made contributions to the synthesis and study of many biologically active molecules, including glycosyl donors,[12] modified peptides,[13] [14] and glycopolymers.[15] [16] [17] Kiessling's research has used these molecules to probe cell recognition and signal transduction processes (Figure 1).[18] Her research has shown that multivalent ligands (molecules that possess multiple binding groups) can influence receptor-ligand binding mechanisms,[19] activate signaling,[20] and target specific immune responses.[21] These discoveries have potential applications in targeted immunotherapy and disease treatment.[22] [23] Kiessling has received a number of awards and honors in recognition of her research. She received a MacArthur Foundation Fellowship (popularly called the "MacArthur genius grant") in 1999.[24] In 2007, Kiessling was inducted as a member of the United States National Academy of Sciences[25] and in 2017, she received the Tetrahedron Prize for Creativity in Organic Chemistry.[26]

Kiessling is a Fellow of the American Association for the Advancement of Sciences[27] and the American Chemical Society,[28] as well as an elected member of the American Academy of Arts and Sciences,[29] American Philosophical Society,[30] and American Academy of Microbiology.[31] Since 2005, she has served as the founding editor-in-chief of ACS Chemical Biology.[32] [33] [34] Kiessling is also the cofounder of Quintessence Biosciences, a company that is working to translate her technological advances into cures for various diseases.[35] She has been selected as one of the fifty top research and development "Stars to Watch" by Industry Week.[36]

Selected honors and awards

External links

Notes and References

  1. Web site: Laura L. Kiessling – Kiessling Lab. kiesslinglab.com. 17 March 2018 . en-US. 2018-07-31.
  2. Web site: Laura L. Kiessling | Faculty | Biochemistry | UW-Madison. 2016-06-28. Biochem.wisc.edu. 2016-07-02.
  3. kiesslin | UW Madison - Department of Chemistry. Angewandte Chemie International Edition. 52. 19. 5061–5064. 10.1002/anie.201300293. 23568693. 3808988. 2016-07-02. 2013. Fishman. Joshua M.. Kiessling. Laura L..
  4. Web site: Laura L. Kiessling . MacArthur Foundation . 16 March 2022.
  5. News: THE ONE HUNDRED AND FIFTH PRESENTATION OF THE WILLARD GIBBS MEDAL (FOUNDED BY WILLIAM A. CONVERSE) TO PROFESSOR LAURA KIESSLING SPONSORED BY THE CHICAGO SECTION OF THE AMERICAN CHEMICAL SOCIETY FRIDAY, MAY 20, 2016. May 20, 2016. The Chemical Bulletin. 14 June 2017.
  6. Web site: Foundation supports chemical genomics center. news.wisc.edu. en-US. 2018-08-01.
  7. Chemistry-Biology Interface Training Program. Grantome. 2018-08-01. Kiessling. Laura.
  8. Web site: Laura L. Kiessling – Kiessling Lab. kiesslinglab.com. 17 March 2018 . en-US. 2018-07-31.
  9. Web site: Wisconsin Alumni Association. https://web.archive.org/web/20120702224958/http://www.uwalumni.com/home/alumniandfriends/onwisconsin/archives/2001spring/keck.aspx. July 2, 2012. dead. July 18, 2012.
  10. Web site: Chemistry-Biology Interface Research Training Program Institutions. 2015-12-09. Publications.nigms.nih.gov. 2016-07-02.
  11. Web site: ACS Chemical Biology. Laura L. Kiessling. Pubs.acs.org. PDF. 2016-07-02.
  12. Hinklin. Ronald. Kiessling. Laura. 2001. Glycosyl Sulfonylcarbamates: New Glycosyl Donors with Tunable Reactivity. Journal of the American Chemical Society. 123. 14. 3379–3380. 10.1021/ja005735i. 11457079. 37296866.
  13. He. Ye. Hinklin. Ronald. Chang. Jiyoung. Kiessling. Laura. 2004. Stereoselective N-Glycosylation by Staudinger Ligation. Organic Letters. 6. 24. 4479–4482. 10.1021/ol048271s. 15548055. 12143159.
  14. Young. Travis. Kiessling. Laura. 2002. A Strategy for the Synthesis of Sulfated Peptides. Angewandte Chemie. 41. 18. 3449–3451. 10.1002/1521-3773(20020916)41:18<3449::AID-ANIE3449>3.0.CO;2-U. 12298060. 1683738.
  15. Strong. Laura. Kiessling. Laura. 1999. A General Synthetic Route to Defined, Biologically Active Multivalent Arrays. Journal of the American Chemical Society. 121. 26. 6193–6196. 10.1021/ja990223t. 16075014.
  16. Pontrello. Jason. Allen. Matthew. Underbakke. Eric. Kiessling. Laura. 2005. Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization. Journal of the American Chemical Society. 127. 42. 14536–14537. 10.1021/ja053931p. 16231882. 744172.
  17. May. John. Splain. Rebecca. Brotschi. Christine. Kiessling. Laura. 2009. A tethering mechanism for length control in a processive carbohydrate polymerization. Proceedings of the National Academy of Sciences. 106. 29. 11851–11865. 10.1073/pnas.0901407106. 19571009. 2715488. 2009PNAS..10611851M. free.
  18. Web site: Multivalent Carbohydrates As New and Powerful Probes of Signal Transduction MIT Department of Chemistry. chemistry.mit.edu. en. 2018-08-22.
  19. Gestwicki. Jason. Cairo. Christopher. Strong. Laura. Oetjen. Karolyn. Kiessling. Laura. 2002. Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture. Journal of the American Chemical Society. 124. 50. 14922–14933. 10.1021/ja027184x. 12475334. 1492819.
  20. Gestwicki. Jason. Kiessling. Laura. 2002. Inter-receptor communication through arrays of bacterial chemoreceptors. Nature. 415. 6867. 81–84. 10.1038/415081a. 11780121. 2002Natur.415...81G. 4401992.
  21. Courtney. Adam. Puffer. Erik. Pontrello. Jason. Yang. Zhi-Qiang. Kiessling. Laura. 2009. Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation. Proceedings of the National Academy of Sciences. 106. 8. 2500–2505. 10.1073/pnas.0807207106. 19202057. 2650292. 2009PNAS..106.2500C. free.
  22. Web site: Researchers Open New Line of Attack on Tuberculosis NSF - National Science Foundation. www.nsf.gov. en. 2018-08-22.
  23. Carlson. Coby. Mowery. Patricia. Owen. Robert. Dykhuizen. Emily. Kiessling. Laura. 2007. Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions. ACS Chemical Biology. 2. 2. 119–127. 10.1021/cb6003788. 17291050. 10.1.1.590.9531.
  24. Web site: MacArthur Fellows Program — MacArthur Foundation. Macfound.org. 2016-07-02.
  25. Web site: Laura L. Kiessling . National Academy of Sciences Member Directory . 16 March 2022.
  26. Book: Tetrahedron Prize for Creativity in Organic Chemistry. 2018-07-30.
  27. Web site: AAAS - The World's Largest General Scientific Society |. Php.aaas.org. https://web.archive.org/web/20140115191304/http://php.aaas.org/about/aaas_fellows/list.php. 2014-01-15. dead. 2016-07-02.
  28. Web site: 2010 ACS Fellows | ACS News | Chemical & Engineering News. Pubs.acs.org. 2016-07-02.
  29. Web site: Alphabetical Index of Active Members. Amacad.org. 2016-07-02. https://web.archive.org/web/20160527025239/http://www.amacad.org/members/alphaList.pdf. 2016-05-27. dead.
  30. Web site: ACS Chemical Biology EIC Laura L. Kiessling Elected to the American Philosophical Society. Key. Ellie. 2017-05-09. ACS Axial. 2018-07-30.
  31. Web site: Fellows Directory. https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory. August 7, 2011. dead. October 8, 2011.
  32. Web site: Laura Kiessling. https://web.archive.org/web/20120313235234/http://archives.microbeworld.org/scientists/interviews/LauraKiessling.aspx. March 13, 2012. dead. July 18, 2012.
  33. Web site: Two faculty elected to National Academy of Sciences. Sakai. Jill. 2007-05-01. News.wisc.edu. 2016-07-02.
  34. Web site: Laura Kiessling. 12 September 2012. Wisconsinacademy.org. 2016-07-02.
  35. Web site: Quintessence Biosciences, Inc. https://web.archive.org/web/20121008005050/http://www.quintbio.com/science.asp. October 8, 2012. dead. July 18, 2012.
  36. Web site: 50 R&D Stars To Watch. Vivian Pospisil. 2004-12-21. Industryweek.com. 2016-07-02.
  37. Web site: Doughty . Danielle . 2022-10-17 . Laura Kiessling Elected to National Academy of Medicine . 2022-10-17 . MIT Department of Chemistry . en-US.
  38. Web site: Kiessling Awarded 2019 Centenary Prize – MIT Department of Chemistry. 13 May 2019 . en-US. 2019-05-14.
  39. Web site: ACS Chemical Biology EIC Laura L. Kiessling Elected to the American Philosophical Society. Key. Ellie. 2017-05-09. ACS Axial. 2018-07-30.
  40. Web site: ACS Chemical Biology EIC Laura L. Kiessling Wins 2016 Gibbs Award. Stanchak. Jesse. 2016-03-16. ACS Axial. 2018-07-30.
  41. Web site: ACS 2014 National Award Winners September 9, 2013 Issue - Vol. 91 Issue 36 Chemical & Engineering News. cen.acs.org. 2016-10-09.
  42. Web site: 2010 ACS Fellows | ACS News | Chemical & Engineering News. Pubs.acs.org. 2016-07-02.
  43. Web site: John Simon Guggenheim Foundation | Fellows. 2014-06-20. Gf.org. 2016-07-02.
  44. Web site: National Academy of Sciences. Nas.nasonline.org. 2016-07-02.
  45. Web site: Fellows Directory. https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory. August 7, 2011. dead. October 8, 2011.
  46. Web site: American Chemical Society - American Chemical Society. Portal.acs.org. 2016-07-02.
  47. Web site: Alphabetical Index of Active Members. Amacad.org. 2016-07-02. https://web.archive.org/web/20160527025239/http://www.amacad.org/members/alphaList.pdf. 2016-05-27. dead.
  48. Web site: AAAS - The World's Largest General Scientific Society |. Php.aaas.org. https://web.archive.org/web/20140115191304/http://php.aaas.org/about/aaas_fellows/list.php. 2014-01-15. dead. 2016-07-02.
  49. Web site: Arthur C. Cope Scholar Awards. Portal.acs.org. 2018-07-30.

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