| EGF, latrophilin and seven transmembrane domain containing 1 | |
| Hgncid: | 20822 |
| Symbol: | ELTD1 |
| Altsymbols: | ETL |
| Entrezgene: | 64123 |
| Refseq: | NM_022159 |
| Uniprot: | Q9HBW9 |
| Chromosome: | 1 |
| Arm: | p33 |
| Band: | -p32 |
| latrophilin 1 | |
| Hgncid: | 20973 |
| Symbol: | LPHN1 |
| Altsymbols: | KIAA0821, CIRL1, LEC2 |
| Entrezgene: | 22859 |
| Refseq: | NM_014921 |
| Uniprot: | O94910 |
| Chromosome: | 19 |
| Arm: | p |
| Band: | 13.2 |
| latrophilin 2 | |
| Hgncid: | 18582 |
| Symbol: | LPHN2 |
| Altsymbols: | LPHH1, KIAA0786, LEC1 |
| Entrezgene: | 23266 |
| Omim: | 607018 |
| Refseq: | NM_012302 |
| Uniprot: | O95490 |
| Chromosome: | 1 |
| Arm: | p |
| Band: | 31.1 |
| latrophilin 3 | |
| Hgncid: | 20974 |
| Symbol: | LPHN3 |
| Altsymbols: | KIAA0768, LEC3 |
| Entrezgene: | 23284 |
| Refseq: | NM_015236 |
| Uniprot: | Q9HAR2 |
| Chromosome: | 4 |
| Arm: | q |
| Band: | 13.1 |
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]
The precise functions of latrophilins remain unknown. Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]