Latrophilin 2 Explained
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.[1] [2]
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.
See also
Further reading
- Südhof TC . alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins . Annual Review of Neuroscience . 24 . 1 . 933–62 . 2001 . 11520923 . 10.1146/annurev.neuro.24.1.933 .
- Ushkaryov YA, Volynski KE, Ashton AC . The multiple actions of black widow spider toxins and their selective use in neurosecretion studies . Toxicon . 43 . 5 . 527–42 . Apr 2004 . 15066411 . 10.1016/j.toxicon.2004.02.008 .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 5 . 277–86 . Oct 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .
- White GR, Varley JM, Heighway J . Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer . Oncogene . 17 . 26 . 3513–9 . Dec 1998 . 10030676 . 10.1038/sj.onc.1202487 . free .
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM . The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins . The Journal of Biological Chemistry . 275 . 42 . 32387–90 . Oct 2000 . 10964907 . 10.1074/jbc.C000490200 . free .
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . Jul 2004 . 15203201 . 10.1016/j.ygeno.2003.12.004 .
- Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE . Discovery of tissue-specific exons using comprehensive human exon microarrays . Genome Biology . 8 . 4 . R64 . 2007 . 17456239 . 1896007 . 10.1186/gb-2007-8-4-r64 . free .
Notes and References
- White GR, Varley JM, Heighway J . Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1491 . 1–3 . 75–92 . Apr 2000 . 10760572 . 10.1016/s0167-4781(00)00020-8 .
- Web site: Entrez Gene: LPHN2 latrophilin 2.