Large neutral amino acids transporter small subunit 2 explained

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.^{[1] [2] [3]}

See also

• Heterodimeric amino acid transporter
• Solute carrier family

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Rossier G, Meier C, Bauch C, etal . LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine . J. Biol. Chem. . 274 . 49 . 34948–54 . 2000 . 10574970 . 10.1074/jbc.274.49.34948 . free .
• Bassi MT, Sperandeo MP, Incerti B, etal . SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family . Genomics . 62 . 2 . 297–303 . 2000 . 10610726 . 10.1006/geno.1999.5978 .
• Bröer A, Friedrich B, Wagner CA, etal . Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains . Biochem. J. . 355 . Pt 3 . 725–31 . 2001 . 10.1042/bj3550725 . 11311135 . 1221788 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Liu X, Charrier L, Gewirtz A, etal . CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia . J. Biol. Chem. . 278 . 26 . 23672–7 . 2003 . 12716892 . 10.1074/jbc.M302777200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Li S, Whorton AR . Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols . J. Biol. Chem. . 280 . 20 . 20102–10 . 2005 . 15769744 . 10.1074/jbc.M413164200 . free .
• Kühne A, Kaiser R, Schirmer M, etal . Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan . Pharmacogenet. Genomics . 17 . 7 . 505–17 . 2007 . 17558306 . 10.1097/FPC.0b013e3280ea77cd . 25402443 .

Notes and References

1. Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G . SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance . Nat Genet . 21 . 3 . 297–301 . Mar 1999 . 10080183 . 10.1038/6815 . 38960307 .
2. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M . Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids . J Biol Chem . 274 . 28 . 19738–44 . Aug 1999 . 10391915 . 10.1074/jbc.274.28.19738 . free . 2445/177123 . free .
3. Web site: Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8.