Large neutral amino acids transporter small subunit 1 explained

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene.^{[1] [2]}

See also

• Heterodimeric amino acid transporter

Further reading

• Kaira K, Oriuchi N, Imai H, etal . Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma. . Lung Cancer . 66 . 1 . 120–6 . 2009 . 19171406 . 10.1016/j.lungcan.2008.12.015 .
• Verrey F, Jack DL, Paulsen IT, etal . New glycoprotein-associated amino acid transporters. . J. Membr. Biol. . 172 . 3 . 181–92 . 1999 . 10568788 . 10.1007/s002329900595. 25962115 .
• Nawashiro H, Otani N, Shinomiya N, etal . L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. . Int. J. Cancer . 119 . 3 . 484–92 . 2006 . 16496379 . 10.1002/ijc.21866 . 41965333 . free .
• Nawashiro H, Otani N, Uozumi Y, etal . High expression of L-type amino acid transporter 1 in infiltrating glioma cells. . Brain Tumor Pathol . 22 . 2 . 89–91 . 2005 . 18095110 . 10.1007/s10014-005-0188-z . 22818900 .
• Ohno Y, Suda K, Masuko K, etal . Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1. . Cancer Sci. . 99 . 5 . 1000–7 . 2008 . 18294274 . 10.1111/j.1349-7006.2008.00770.x . 205233796 . free . 11160021 .
• Vumma R, Wiesel FA, Flyckt L, etal . Functional characterization of tyrosine transport in fibroblast cells from healthy controls. . Neurosci. Lett. . 434 . 1 . 56–60 . 2008 . 18262359 . 10.1016/j.neulet.2008.01.028 . 25493412 .
• Endou H, Kanai Y . [Amino acid transporter molecule as a drug target] . Nippon Yakurigaku Zasshi . 114 . 11P–16P . 1999 . Suppl 1 . 10629848 . 10.1254/fpj.114.supplement_11. free .
• Nakanishi K, Ogata S, Matsuo H, etal . Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. . Virchows Arch. . 451 . 3 . 681–90 . 2007 . 17622555 . 10.1007/s00428-007-0457-9 . 2540836 .
• Kaira K, Oriuchi N, Imai H, etal . L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas. . J Surg Oncol . 99 . 7 . 433–8 . 2009 . 19347882 . 10.1002/jso.21277 . 5381963 .
• Anderson BM, Schnetz-Boutaud NC, Bartlett J, etal . Examination of association of genes in the serotonin system to autism. . Neurogenetics . 10 . 3 . 209–16 . 2009 . 19184136 . 10.1007/s10048-009-0171-7 . 2753863.
• Ring BZ, Seitz RS, Beck RA, etal . A novel five-antibody immunohistochemical test for subclassification of lung carcinoma. . Mod. Pathol. . 22 . 8 . 1032–43 . 2009 . 19430419 . 10.1038/modpathol.2009.60 . free .
• Kaira K, Oriuchi N, Imai H, etal . Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung. . Pathol. Res. Pract. . 204 . 8 . 553–61 . 2008 . 18440724 . 10.1016/j.prp.2008.02.003 .
• Kobayashi K, Ohnishi A, Promsuk J, etal . Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. . Neurosurgery . 62 . 2 . 493–503; discussion 503–4 . 2008 . 18382329 . 10.1227/01.neu.0000316018.51292.19 .
• Kühne A, Kaiser R, Schirmer M, etal . Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan. . Pharmacogenet. Genomics . 17 . 7 . 505–17 . 2007 . 17558306 . 10.1097/FPC.0b013e3280ea77cd . 25402443 .
• Kaira K, Oriuchi N, Imai H, etal . Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer. . Br. J. Cancer . 98 . 4 . 742–8 . 2008 . 18253116 . 10.1038/sj.bjc.6604235 . 2259171.
• Bröer S . Amino acid transport across mammalian intestinal and renal epithelia. . Physiol. Rev. . 88 . 1 . 249–86 . 2008 . 18195088 . 10.1152/physrev.00018.2006 .
• Kaira K, Oriuchi N, Imai H, etal . l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms. . Cancer Sci. . 99 . 12 . 2380–6 . 2008 . 19018776 . 10.1111/j.1349-7006.2008.00969.x . 24560556 . free . 11159766 .
• Imai H, Kaira K, Oriuchi N, etal . L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer. . Histopathology . 54 . 7 . 804–13 . 2009 . 19635099 . 10.1111/j.1365-2559.2009.03300.x . 5787861 .
• Shennan DB, Thomson J . Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. . Oncol. Rep. . 20 . 4 . 885–9 . 2008 . 18813831 . 10.3892/or_00000087. free .
• Sakata T, Ferdous G, Tsuruta T, etal . L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. . Pathol. Int. . 59 . 1 . 7–18 . 2009 . 19121087 . 10.1111/j.1440-1827.2008.02319.x . 32050759 .

Notes and References

1. Web site: Entrez Gene: solute carrier family 7 (cationic amino acid transporter.
2. Web site: UniProt . www.uniprot.org.