Lankenau Institute for Medical Research explained

Lankenau Institute
for Medical Research
Established:1927
Head Label:President
and CEO
Head:George C. Prendergast
Address:Wynnewood, Pennsylvania

Lankenau Institute for Medical Research (LIMR), founded in 1927, is a nonprofit, biomedical research institute located on the campus of Lankenau Medical Center in Wynnewood, Pennsylvania, serving as the research division of the Main Line Health System in suburban Philadelphia.[1] LIMR focuses on studies of cancer, cardiovascular, autoimmune, gastrointestinal and other diseases. It houses a center for population health research.[2]

History

LIMR was one of the first U.S. research institutes to focus on cancer when it was founded in 1927. It was formerly known as the Lankenau Hospital Research Institute (LHRI) until 1980 and the Lankenau Medical Research Center (LMRC) from 1981-1999.[3] Starting in 1941, LHRI also housed the Institute for Cancer Research (ICR), until the ICR was merged with the former American Oncology Hospital to create Fox Chase Cancer Center in 1974.[4] [5]

LHRI researcher David Hungerford is credited with the discovery of the first genetic abnormality in cancer, called the Philadelphia chromosome.[6] It is detected in the vast majority of patients suffering from myelogenous leukemia. The first molecule-targeted drug to be created for cancer therapy, Gleevec (imatinib), acts by blocking this genetic abnormality.

LHRI researcher Baruch Blumberg is credited with the discovery of the hepatitis B virus and a blood test to detect it, as recognized by the 1976 Nobel Prize for Physiology or Medicine.[7]

LIMR carried out research into the role of IDO (indoleamine 2,3-dioxygenase) in cancer, including the first experimental therapeutics to directly inhibit this enzyme, which modifies inflammatory processes in cancer, autoimmune disease, retinopathy, cardiovascular disease, and other disorders.[8] [9] [10]

Background

George C. Prendergast is the President and CEO of LIMR since 2004.[11] [12]

Grants and awards

External links

39.9888°N -75.2561°W

Notes and References

  1. Web site: The man behind Lankenau Hospital . inquirer.com . 30 August 2013.
  2. Web site: Main Line research institute turns to Jefferson for invention-licensing help . bizjournals.com . 23 August 2019.
  3. Web site: The man behind Lankenau Hospital . inquirer.com . 30 August 2013.
  4. Web site: Lankenau Institute For Medical Research - GovTribe . govtribe.com . 21 September 2007.
  5. Web site: The man behind Lankenau Hospital . inquirer.com . 30 August 2013.
  6. Nowell. Peter C.. 2007-08-01. Discovery of the Philadelphia chromosome: a personal perspective . Journal of Clinical Investigation. 117. 8. 2033–2035. 10.1172/JCI31771 . 1934591. 17671636.
  7. Web site: Physiology or Medicine 1976 - NobelPrize.org . nobelprize.org . 22 December 2009.
  8. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer . International Review of Cell and Molecular Biology . 2018 . 29413890 . Prendergast . G. C. . Malachowski . W. J. . Mondal . A. . Scherle . P. . Muller . A. J. . 336 . 175–203 . 10.1016/bs.ircmb.2017.07.004 . 6054468 . 9780128146514 .
  9. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape . Immunological Reviews . 2008 . 18364004 . 22 April 2008. Katz . J. B. . Muller . A. J. . Prendergast . G. C. . 222 . 206–221 . 10.1111/j.1600-065X.2008.00610.x . 8133439 .
  10. Web site: 10 ways Philadelphia is leading the war on cancer . bizjournals.com . 17 April 2015.
  11. Web site: George C. Prendergast, PhD . mainlinehealth.org . 18 June 2004.
  12. Jefferson and Lankenau Institute of Medical Research Collaborate on Cancer Research . Jefferson Surgical Solutions . 26 October 2012 . 7 . 2 . 26 October 2012.
  13. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge . 2016 . 5063270 . Antzelevitch . C. . Yan . G. X. . Ackerman . M. J. . Borggrefe . M. . Corrado . D. . Guo . J. . Gussak . I. . Hasdemir . C. . Horie . M. . Huikuri . H. . Ma . C. . Morita . H. . Nam . G. B. . Sacher . F. . Shimizu . W. . Viskin . S. . Wilde . A. A. . Journal of Arrhythmia . 32 . 5 . 315–339 . 10.1016/j.joa.2016.07.002 . 27761155 .
  14. Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective . 2014 . 4152783 . Gourevitch . D. . Kossenkov . A. V. . Zhang . Y. . Clark . L. . Chang . C. . Showe . L. C. . Heber-Katz . E. . Advances in Wound Care . 3 . 9 . 592–603 . 10.1089/wound.2014.0528 . 25207202 .
  15. Web site: IDO2 Targeting for pancreatic cancer treatment . grantome.com . 1 November 2012.
  16. Web site: Targeting Increased Polyamine Transport of Resistant Melanomas . apps.dtic.mil . 7 September 2017.
  17. Retrofitting the battlements: tight junction remodeling as a novel antimicrobial approach . Future Medicinal Chemistry . 2015 . 10.4155/fmc.14.146 . 13 January 2015. Mullin . James M. . Raines . Jonathan . Livornese . Lawrence L. . 7 . 1 . 9–13 . 25582329 .
  18. Monoclonal antibodies from a patient with anti-NMDA receptor encephalitis . Annals of Clinical and Translational Neurology . 2018 . 10.1002/acn3.592 . Sharma . Rashmi . Al-Saleem . Fetweh H. . Panzer . Jessica . Lee . Jiwon . Puligedda . Rama Devudu . Felicori . Liza F. . Kattala . Chandana Devi . Rattelle . Amy J. . Ippolito . Gregory . Cox . Robert H. . Lynch . David R. . Dessain . Scott K. . 5 . 8 . 935–951 . 30128318 . 6093837 .
  19. Web site: New Drug Discovery Paradigms for Synucleinopathies . grantome.com . 1 May 2018.
  20. Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice . Arthritis and Rheumatism . 2012 . 22294267 . Pigott . E. . Mandik-Nayak . L. . 64 . 7 . 2169–2178 . 10.1002/art.34406 . 3351581 .

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