Chen Lan-bo explained

Lan Bo Chen
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Chen Lan-bo is a Taiwanese biotechnologist. He was a professor of pathology at Harvard Medical School between 1977 and 2004 and is the author of over 250 publications. He is also a member of Boston's Dana-Farber Cancer Institute[1] in the department of cancer and biology and a member of the Academia Sinica of Taiwan.

Early life and education

Chen was born on 23 August 1943 in Yilan, Taiwan. He received his B.S. in chemistry from National Taiwan University in Taiwan, followed by his Ph.D. in cell biology at Massachusetts Institute of technology.[2] [3]

Research and career

Chen did postdoctoral research work for one year supervised by James D. Watson, the Nobel laureate who co-discovered the DNA double helix structure.[4] He did research on the mitogenicity of thrombin and surface alterations on mouse splenocytes and also on intercellular LETS glycoprotein matrices.[5]

He is also a cell biologist making seminal findings in the multiple fields of molecular cell biology and cancer biology, including the discovery of rhodamine 123 for highly specific fluorescent localization of mitochondria in living cells, removal of carcinoma cells from contaminated bone marrow using the lipophilic cation, identification of human cancer line without any Intermediate filaments, and also on the development of the rare event detection system to detect lung cancer cells from Body fluids.[6] [7] [8]

In the early days of his career, he worked as a Senior Staff investigator at the Cold Spring Harbor Laboratories, before becoming a full and emeritus professor of pathology at the Harvard Medical School with laboratories at the Dana-Farber Cancer Institute.

Chen founded Synta Pharmaceuticals Corporation,[9] [10] and in 2007, was invited to serve on the founding board of directors for Yu Chang Biologics Company, also known as TaiMed Biologics Company.[11] [12] Chen was supportive of Tsai Ing-wen's 2012 presidential campaign after Tsai's involvement with TaiMed became a subject of investigation.[13] [14] Chen described the Sunflower Student Movement of 2014 as "the mightiest movement Taiwan has seen in several decades" and said that "this student movement will kick-start the development of Taiwan’s biotech industry."[15] In January 2019, Chen signed a petition opposing the confirmation of Kuan Chung-ming as president of National Taiwan University.[16]

Awards and honors

Chen received the American Cancer Society Professor award,[17] and and, in 1996, was elected as a member of the Academia Sinica.[18] He also served as a former board member at Madrigal Pharmaceuticals.[19]

Publications

Chen has published over 250 publications.[20] His contributions include the following:

Notes and References

  1. Web site: https://www.bizjournals.com/boston/stories/2002/11/11/story5.html. www.bizjournals.com. 2020-01-20.
  2. Web site: Dr. Lan Bo Chen Delos Capital. en-US. 2020-01-20.
  3. Web site: Lan-Bo Chen, CHO Pharma Inc: Profile and Biography - Bloomberg Markets. 2020-01-20. Bloomberg.com.
  4. Web site: Delos Capital Announces the Launch of Curamir Therapeutics Inc. with a $10 Million Series A to Develop miRNA-based Cancer Therapeutics. BioSpace. en-US. 2020-01-20.
  5. Chen. L. B.. Teng. N. N. H.. Buchanan. J. M.. 1976-08-01. Mitogenicity of thrombin and surface alterations on mouse splenocytes. Experimental Cell Research. 101. 1. 41–46. 10.1016/0014-4827(76)90409-2. 986310. 0014-4827.
  6. Lampidis. Theodore J.. Salet. Christian. Moreno. Giuliana. Chen. Lan Bo. 1984-09-01. Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture. Agents and Actions. en. 14. 5. 751–757. 10.1007/BF01978920. 6475672. 1341638. 1420-908X.
  7. Johnson. Lincoln V.. Summerhayes. Ian C.. Chen. Lan Bo. 1982-01-01. Decreased uptake and retention of rhodamine 123 by mitochondria in feline sarcoma virus-transformed mink cells. Cell. 28. 1. 7–14. 10.1016/0092-8674(82)90369-5. 6279315. 38032526. 0092-8674.
  8. Lampidis. T. J.. Bernal. S. D.. Summerhayes. I. C.. Chen. L. B.. February 1983. Selective toxicity of rhodamine 123 in carcinoma cells in vitro. Cancer Research. 43. 2. 716–720. 0008-5472. 6848187.
  9. News: Willis . Randall C. . Bad news for Beantown?. 1 January 2019 . ACS Publications . September 2004.
  10. News: Connolly . Allison . $45M in private financing vaults Synta's profile . 2 January 2019 . Boston Business Journal . 11 November 2002.
  11. News: New AIDS research firm to be created . 1 January 2019 . Taipei Times . 14 September 2007.
  12. News: Kao . Cameron . Biomedical industry gets a clean bill of health: expert . 1 January 2019 . Taipei Times . 8 July 2014.
  13. News: Chang . Rich . Tsai cleared of Yu Chang allegations . 1 January 2019 . Taipei Times . 15 August 2012.
  14. News: Wang . Chris . 2012 ELECTIONS: Key figures speak out to support Tsai . 1 January 2019 . Taipei Times . 16 December 2011.
  15. News: Huang . Tien-lien . Sunflower movement helped lift economy . 1 January 2019 . Taipei Times . 10 July 2014.
  16. News: Maxon . Ann . Academics ask ministry to annul Kuan appointment . 2 January 2019 . Taipei Times . 2 January 2019.
  17. Web site: sinica.edu. sinica.edu.tw.
  18. News: Lan-Bo Chen . 8 September 2023 . Academia Sinica.
  19. Web site: Dr. Lan Bo Chen Ph.D.- Executive Bio, Work History, and Contacts - Equilar BoardEdge. people.equilar.com. 2020-01-20.
  20. Web site: Lan Bo Chen - Google Scholar Citations. scholar.google.com. 2019-12-12.
  21. Chen. Lan Bo. 1988-11-01. Mitochondrial Membrane Potential in Living Cells. Annual Review of Cell Biology. 4. 1. 155–181. 10.1146/annurev.cb.04.110188.001103. 3058159. 0743-4634.
  22. Chen. Lan Bo. Murray. Andrew. Segal. Rosalind A.. Bushnell. Anne. Walsh. Marcia L.. 1978-06-01. Studies on intercellular LETS glycoprotein matrices. Cell. English. 14. 2. 377–391. 10.1016/0092-8674(78)90123-X. 0092-8674. 667946. 21963330. subscription.
  23. Chen. L. B.. Gallimore. P. H.. McDougall. J. K.. 1976-10-01. Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proceedings of the National Academy of Sciences. en. 73. 10. 3570–3574. 10.1073/pnas.73.10.3570. 0027-8424. 431159. 1068469. 1976PNAS...73.3570C. free .
  24. Book: Chen, Lan Bo. Chapter 7 Fluorescent Labeling of Mitochondria. 1988-01-01. http://www.sciencedirect.com/science/article/pii/S0091679X08601909. Methods in Cell Biology. 29. 103–123. Wang. Yu-Li. Wang Yu-li. Academic Press. 10.1016/s0091-679x(08)60190-9. 2643756. 2019-12-12. Taylor. D. Lansing. Jeon. K. W.. Fluorescence Microscopy of Living Cells in Culture Part A . Fluorescent Analogs, Labeling Cells, and Basic Microscopy. 9780125641296.
  25. Chen. L. B.. Maitland. N.. Gallimore. P. H.. McDougall. J. K.. 1977-04-01. Detection of the large external transformation-sensitive protein on some epithelial cells. Experimental Cell Research. 106. 1. 39–46. 10.1016/0014-4827(77)90238-5. 852517. 0014-4827.
  26. Chen. L. B.. Teng. N. N. H.. Buchanan. J. M.. 1976-08-01. Mitogenicity of thrombin and surface alterations on mouse splenocytes. Experimental Cell Research. 101. 1. 41–46. 10.1016/0014-4827(76)90409-2. 986310. 0014-4827.
  27. Chen. Lan Bo. Buchanan. John M.. 1975. Plasminogen-Independent Fibrinolysis by Proteases Produced by Transformed Chick Embryo Fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 72. 3. 1132–1136. 0027-8424. 64433. 10.1073/pnas.72.3.1132. 165484. 432480. 1975PNAS...72.1132C. free .
  28. Chen. Lan Bo. Burridge. Keith. Murray. Andrew. Walsh. Marcia L.. Copple. Christine D.. Bushnell. Anne. McDougall. James K.. Gallimore. Phillip H.. 1978. Modulation of Cell Surface Glycocalyx: Studies on Large, External, Transformation-Sensitive Protein*. Annals of the New York Academy of Sciences. en. 312. 1. 366–381. 10.1111/j.1749-6632.1978.tb16814.x. 386883. 1749-6632. 1978NYASA.312..366C. 32711763.
  29. Davies. Faith E.. Dring. Ann M.. Li. Cheng. Rawstron. Andrew C.. Shammas. Masood A.. O'Connor. Sheila M.. Fenton. James A. L.. Hideshima. Teru. Chauhan. Dharminder. Tai. Isabella T.. Robinson. Elizabeth. 15676924. 2003-12-15. Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood. en. 102. 13. 4504–4511. 10.1182/blood-2003-01-0016. 12947006. 0006-4971. free.
  30. Yang. Xiuwei. Claas. Christoph. Kraeft. Stine-Kathrein. Chen. Lan Bo. Wang. Zemin. Kreidberg. Jordan A.. Hemler. Martin E.. 2002-02-04. Palmitoylation of Tetraspanin Proteins: Modulation of CD151 Lateral Interactions, Subcellular Distribution, and Integrin-dependent Cell Morphology. Molecular Biology of the Cell. 13. 3. 767–781. 10.1091/mbc.01-05-0275. 1059-1524. 99597. 11907260.

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