Laminin subunit alpha-1 explained

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.^{[1] [2]}

Interactions

Laminin, alpha 1 has been shown to interact with FBLN2.^{[3] [4]}

Role in pathology

Mutations of the LAMA1 gene cause the Poretti–Boltshauser syndrome.

Further reading

• Haaparanta T, Uitto J, Ruoslahti E, Engvall E . Molecular cloning of the cDNA encoding human laminin A chain. . Matrix . 11 . 3 . 151–60 . 1991 . 1714537 . 10.1016/s0934-8832(11)80153-8.
• Nissinen M, Vuolteenaho R, Boot-Handford R, etal . Primary structure of the human laminin A chain. Limited expression in human tissues . Biochem. J. . 276 (Pt 2) . Pt 2. 369–79 . 1991 . 2049067 . 10.1042/bj2760369. 1151101 .
• Taraboletti G, Rao CN, Krutzsch HC, etal . Sulfatide-binding domain of the laminin A chain . J. Biol. Chem. . 265 . 21 . 12253–8 . 1990 . 10.1016/S0021-9258(19)38338-3 . 2373692 . free .
• Olsen D, Nagayoshi T, Fazio M, etal . Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells . Lab. Invest. . 60 . 6 . 772–82 . 1989 . 2733383 .
• Leivo I, Engvall E . C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast . J. Cell Biol. . 103 . 3 . 1091–100 . 1986 . 3488995 . 10.1083/jcb.103.3.1091 . 2114300 .
• Wewer UM, Gerecke DR, Durkin ME, etal . Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas . Genomics . 24 . 2 . 243–52 . 1995 . 7698745 . 10.1006/geno.1994.1612 .
• Yamada H, Shimizu T, Tanaka T, etal . Dystroglycan is a binding protein of laminin and merosin in peripheral nerve . FEBS Lett. . 352 . 1 . 49–53 . 1994 . 7925941 . 10.1016/0014-5793(94)00917-1 . 17529055 .
• Moser TL, Enghild JJ, Pizzo SV, Stack MS . The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator . J. Biol. Chem. . 268 . 25 . 18917–23 . 1993 . 10.1016/S0021-9258(17)46714-7 . 8360181 . free .
• Yurchenco PD, Sung U, Ward MD, etal . Recombinant laminin G domain mediates myoblast adhesion and heparin binding . J. Biol. Chem. . 268 . 11 . 8356–65 . 1993 . 10.1016/S0021-9258(18)53103-3 . 8463343 . free .
• Ancsin JB, Kisilevsky R . Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A . J. Biol. Chem. . 272 . 1 . 406–13 . 1997 . 8995276 . 10.1074/jbc.272.1.406 . 37912337 . free.
• Zahedi K . Characterization of the binding of serum amyloid P to laminin . J. Biol. Chem. . 272 . 4 . 2143–8 . 1997 . 8999915 . 10.1074/S0021-9258(19)78482-8 . free .
• Utani A, Nomizu M, Yamada Y . Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences . J. Biol. Chem. . 272 . 5 . 2814–20 . 1997 . 9006922 . 10.1074/jbc.272.5.2814 . 24800195 . free .
• Cáceres J, Brandan E . Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans . J. Cell. Biochem. . 65 . 2 . 145–58 . 1997 . 9136074 . 10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U . 43911847 .
• Chen M, Marinkovich MP, Veis A, etal . Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin . J. Biol. Chem. . 272 . 23 . 14516–22 . 1997 . 9169408 . 10.1074/jbc.272.23.14516 . 7310763 . free .
• Schuger L, Skubitz AP, Zhang J, etal . Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development . J. Cell Biol. . 139 . 2 . 553–62 . 1997 . 9334356 . 10.1083/jcb.139.2.553 . 2139794 .
• Mrowiec T, Melchar C, Górski A . HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium . Arch. Immunol. Ther. Exp. (Warsz.) . 45 . 2–3 . 255–9 . 1998 . 9597096 .
• O'Grady P, Thai TC, Saito H . The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR . J. Cell Biol. . 141 . 7 . 1675–84 . 1998 . 9647658 . 10.1083/jcb.141.7.1675 . 2133008 .
• Ettner N, Göhring W, Sasaki T, etal . The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan . FEBS Lett. . 430 . 3 . 217–21 . 1998 . 9688542 . 10.1016/S0014-5793(98)00601-2 . 84569969 . free .
• Ludwig HC, Rausch S, Schallock K, Markakis E . Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry . Anticancer Res. . 19 . 3A . 1747–52 . 1999 . 10470109 .

Notes and References

1. Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J . Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3 . Genomics . 5 . 4 . 932–5 . January 1990 . 2591971 . 10.1016/0888-7543(89)90136-5 .
2. Web site: Entrez Gene: LAMA1 laminin, alpha 1.
3. Utani . A . Nomizu M . Yamada Y . January 1997 . Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences . J. Biol. Chem. . 272 . 5 . 2814–20 . 0021-9258. 9006922 . 10.1074/jbc.272.5.2814 . 24800195 . free .
4. Talts . J F . Sasaki T . Miosge N . Göhring W . Mann K . Mayne R . Timpl R . November 2000 . Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues . J. Biol. Chem. . 275 . 45 . 35192–9 . 0021-9258. 10934193 . 10.1074/jbc.M003261200 . 36521395 . free .