Lamin B1 Explained

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.[1] [2] [3]

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.

Interactions

LMNB1 has been shown to interact with Thymopoietin.[4] [5] When double-strand breaks are induced in DNA by ionizing radiation, lamin B1 promotes repair of the breaks, as well as cell survival, by maintaining the level of the RAD51 protein that is employed in homologous recombinational repair.[6]

Pathology

Mutations affecting the LMNB1 gene cause autosomal dominant adult-onset demyelinating leukodystrophy.

See also

Further reading

Notes and References

  1. Lin F, Worman HJ . Structural organization of the human gene (LMNB1) encoding nuclear lamin B1 . Genomics . 27 . 2 . 230–6 . Nov 1995 . 7557986 . 10.1006/geno.1995.1036 . free .
  2. Wydner KL, McNeil JA, Lin F, Worman HJ, Lawrence JB . Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization . Genomics . 32 . 3 . 474–8 . Feb 1997 . 8838815 . 10.1006/geno.1996.0146 . free .
  3. Web site: Entrez Gene: LMNB1 lamin B1.
  4. Furukawa . K . Kondo T . Feb 1998 . Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin . Eur. J. Biochem. . 251 . 3 . 729–33 . GERMANY. 0014-2956. 9490046 . 10.1046/j.1432-1327.1998.2510729.x . free .
  5. Foisner . R . Gerace L . Jul 1993 . Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation . Cell . 73 . 7 . 1267–79 . UNITED STATES. 0092-8674. 8324822 . 10.1016/0092-8674(93)90355-T . 10641633 .
  6. Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. FASEB J. 2015 Jun;29(6):2514-25. doi: 10.1096/fj.14-265546. Epub 2015 Mar 2. PMID 25733566