Ladinin 1 Explained

Ladinin-1 is a protein that in humans is encoded by the LAD1 gene.^{[1] [2] [3]}

The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme.

Further reading

• Uitto J, Pulkkinen L . Molecular complexity of the cutaneous basement membrane zone . Mol. Biol. Rep. . 23 . 1 . 35–46 . 1997 . 8983017 . 10.1007/BF00357071 . 23991264 .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Benzinger A . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . vanc. Muster N . Koch HB . 3 . Yates Jr . 3rd . Hermeking . H . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Shimizu H . The 97 kDa linear IgA bullous dermatosis antigen is not expressed in a patient with generalized atrophic benign epidermolysis bullosa with a novel homozygous G258X mutation in COL17A1 . J. Invest. Dermatol. . 111 . 5 . 887–92 . 1998 . 9804354 . 10.1046/j.1523-1747.1998.00363.x . vanc. Takizawa Y . Pulkkinen L . 3 . Zone . John J . Matsumoto . Kazuhiko . Saida . Toshiaki . Uitto . Jouni . Nishikawa . Takeji . free .
• Ishiko A . 97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen . J. Invest. Dermatol. . 111 . 1 . 93–6 . 1998 . 9665393 . 10.1046/j.1523-1747.1998.00231.x . vanc. Shimizu H . Masunaga T . 3 . Yancey . Kim B . Giudice . George J . Zone . John J . Nishikawa . Takeji . free .
• Ishiko A . 97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane . J. Invest. Dermatol. . 106 . 4 . 739–43 . 1996 . 8618014 . 10.1111/1523-1747.ep12345793 . vanc. Shimizu H . Masunaga T . 3 . Hashimoto . Takashi . Dmochowski . Marian . Wojnarowska . Fenella . Bhogal . Balbir S. . Black . Martin M. . Nishikawa . Takeji . free .

Notes and References

1. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ . LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells . J Invest Dermatol . 106 . 4 . 734–8 . Jun 1996 . 8618013 . 10.1111/1523-1747.ep12345782 . free .
2. Motoki K, Megahed M, LaForgia S, Uitto J . Mosaad Megahed . Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component . Genomics . 39 . 3 . 323–30 . Apr 1997 . 9119369 . 10.1006/geno.1996.4507 .
3. Web site: Entrez Gene: LAD1 ladinin 1.