Lactate permease family explained
The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) superfamily.[1]
Function
Characterized members of this family possess 15-18 transmembrane segments (TMSs) and are roughly 460-565 amino acyl residues in length.
General transport reaction
Transport reactions catalyzed by functionally characterized members of the LctP family include:[2]
D- or L-lactate or glycolate (out) + H+ (out) → D- or L-lactate or glycolate (in) + H+ (in).
Further reading
- Moraes TF, Reithmeier RA . Membrane transport metabolons . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1818 . 11 . 2687–706 . November 2012 . 22705263 . 10.1016/j.bbamem.2012.06.007 . free .
- Núñez MF, Kwon O, Wilson TH, Aguilar J, Baldoma L, Lin EC . Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli . Biochemical and Biophysical Research Communications . 290 . 2 . 824–9 . January 2002 . 11785976 . 10.1006/bbrc.2001.6255 .
- Rabus R, Jack DL, Kelly DJ, Saier MH . TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters . Microbiology . 145 . 12 . 3431–45 . December 1999 . 10627041 . 10.1099/00221287-145-12-3431 . free .
- Saier MH, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB . Phylogenetic characterization of novel transport protein families revealed by genome analyses . Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes . 1422 . 1 . 1–56 . February 1999 . 10082980 . 10.1016/s0304-4157(98)00023-9.
Notes and References
- Prakash S, Cooper G, Singhi S, Saier MH . The ion transporter superfamily . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1618 . 1 . 79–92 . December 2003 . 14643936 . 10.1016/j.bbamem.2003.10.010 .
- Web site: 2.A.14 The Lactate Permease (LctP) Family. Transporter Classification Database. 2016-03-02.