Labdatriene synthase explained

Labdatriene synthase
Ec Number:	4.2.3.99

Labdatriene synthase (EC 4.2.3.99, OsKSL10 (gene)) is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase ((12E)-9α-labda-8(17),12,14-triene-forming).^[1] This enzyme catalyses the following chemical reaction

9α-copalyl diphosphate

\rightleftharpoons (12E)-9α-labda-8(17),12,14-triene + diphosphate

The enzyme from rice (Oryza sativa) also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate.

Notes and References

1. Morrone D, Hillwig ML, Mead ME, Lowry L, Fulton DB, Peters RJ . Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals . The Biochemical Journal . 435 . 3 . 589–95 . May 2011 . 21323642 . 3723722 . 10.1042/bj20101429 .