| Official Name: | La Penusca, Texas |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Texas#USA |
| Pushpin Label: | La Penusca |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Texas |
| Subdivision Type2: | County |
| Subdivision Name2: | Cameron |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 30 |
| Coordinates: | 26.0778°N -97.4944°W |
| Area Code: | 956 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1374422 |
La Penusca is an unincorporated community in Cameron County, Texas, United States. It is located within the Rio Grande Valley and the Brownsville-Harlingen metropolitan area.
La Penusca consisted of a few scattered farms in the late 1940s and had 27 homes in 1983. There were no population estimates in 2000.
La Penusca is located on the shore of the Resaca de los Cuates, 1miles west of Los Fresnos in central Cameron County.
Today, the community is served by the Los Fresnos Consolidated Independent School District. Children in the community attend Los Fresnos Elementary School, Liberty Memorial Middle School, and Los Fresnos High School.