| Official Name: | La Mesilla |
| Settlement Type: | Municipality |
| Pushpin Map: | Guatemala |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Guatemala |
| Subdivision Type: | Country |
| Subdivision Name: | Guatemala |
| Subdivision Name1: | Huehuetenango |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | La Democracia |
| Population Blank1 Title: | Ethnicities |
| Population Blank1: | Mam, Ladino |
| Population Blank2 Title: | Religions |
| Population Blank2: | Roman Catholicism, Evangelicalism, Maya |
| Coordinates: | 15.6167°N -91.9831°W |
La Mesilla is a village in La Democracia municipality, Huehuetenango Department, Guatemala. It is the home of Peñarol La Mesilla football club.
La Mesilla lies close to the border with Mexico, between Huehuetenango city and Comitán, Mexico.