| La Guadalupe | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Guainía Department |
| Area Total Km2: | 6457 |
| Population Total: | 358 |
| Population Density Metro Km2: | auto |
| Population Urban: | 326 |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation M: | 80 |
La Guadalupe (pronounced as /es/) is a village and municipality in the Guainía Department, Colombia. La Guadalupe borders the corregimiento of San Felipe on the north, Brazil on the south and west, and Venezuela on the East.