| La Grande-Résie | |
| Commune Status: | Commune |
| Coordinates: | 47.3361°N 5.5731°W |
| Insee: | 70443 |
| Postal Code: | 70140 |
| Arrondissement: | Vesoul |
| Canton: | Marnay |
| Mayor: | Dominique Thevenot |
| Term: | 2020 - 2026 |
| Elevation Min M: | 192 |
| Elevation Max M: | 222 |
| Area Km2: | 4.76 |
La Grande-Résie (pronounced as /fr/) is a commune in the Haute-Saône department in the region of Bourgogne-Franche-Comté in eastern France.