LYL1 explained

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.^{[1] [2]}

Interactions

LYL1 has been shown to interact with TCF3^[3] and NFKB1.^[4]

Further reading

• Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ . TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia . Proceedings of the National Academy of Sciences of the United States of America . 88 . 24 . 11416–20 . December 1991 . 1763056 . 53146 . 10.1073/pnas.88.24.11416 . 1991PNAS...8811416X . free .
• Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML . Structure, chromosome mapping, and expression of the mouse Lyl-1 gene . Oncogene . 6 . 6 . 961–8 . June 1991 . 2067848 .
• Saltman DL, Mellentin JD, Smith SD, Cleary ML . Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization . Genes, Chromosomes & Cancer . 2 . 4 . 259–65 . November 1990 . 2268576 . 10.1002/gcc.2870020402 . 103922 .
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia . The EMBO Journal . 13 . 20 . 4831–9 . October 1994 . 7957052 . 395422 . 10.1002/j.1460-2075.1994.tb06809.x.
• Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A . Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers . Genomics . 15 . 1 . 133–45 . January 1993 . 8432525 . 10.1006/geno.1993.1021 .
• Miyamoto A, Cui X, Naumovski L, Cleary ML . Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells . Molecular and Cellular Biology . 16 . 5 . 2394–401 . May 1996 . 8628307 . 231228 . 10.1128/mcb.16.5.2394 .
• Mahajan MA, Park ST, Sun XH . Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins . Oncogene . 12 . 11 . 2343–50 . June 1996 . 8649774 .
• Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D . Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 . Oncogene . 18 . 4 . 995–1005 . January 1999 . 10023675 . 10.1038/sj.onc.1202374 . free .
• Meng YS, Khoury H, Dick JE, Minden MD . Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia . Leukemia . 19 . 11 . 1941–7 . November 2005 . 16094422 . 10.1038/sj.leu.2403836 . free .

Notes and References

1. Mellentin JD, Smith SD, Cleary ML . lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif . Cell . 58 . 1 . 77–83 . July 1989 . 2752424 . 10.1016/0092-8674(89)90404-2 . 24737263 .
2. Web site: Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1.
3. Miyamoto A, Cui X, Naumovski L, Cleary ML . Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells . Molecular and Cellular Biology . 16 . 5 . 2394–401 . May 1996 . 8628307 . 231228 . 10.1128/mcb.16.5.2394 .
4. Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D . Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 . Oncogene . 18 . 4 . 995–1005 . January 1999 . 10023675 . 10.1038/sj.onc.1202374 . free .