LY9 explained

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.^{[1] [2] [3]} LY9 has also recently been designated CD229 (cluster of differentiation 229).

Interactions

LY9 has been shown to interact with SH2D1A.^{[4] [5]}

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–113 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P . Gene structure of the mouse leukocyte cell surface molecule Ly9 . Immunogenetics . 51 . 10 . 788–793 . 2000 . 10970093 . 10.1007/s002510000209 . 23932012 .
• de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P . Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9 . Blood . 97 . 11 . 3513–3520 . 2001 . 11369645 . 10.1182/blood.V97.11.3513 . free .
• Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C . Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP . Blood . 97 . 12 . 3867–3874 . 2001 . 11389028 . 10.1182/blood.V97.12.3867 . free .
• Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C . Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients . J. Biol. Chem. . 276 . 39 . 36809–36816 . 2001 . 11477068 . 10.1074/jbc.M101305200 . free . 2437/230556 . free .
• Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C . Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells . EMBO J. . 20 . 21 . 5840–5852 . 2001 . 11689425 . 125701 . 10.1093/emboj/20.21.5840 .
• Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P . Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors . Immunogenetics . 54 . 6 . 394–402 . 2002 . 12242590 . 10.1007/s00251-002-0483-3 . 38277782 .
• Del Valle JM, Engel P, Martín M . The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) . J. Biol. Chem. . 278 . 19 . 17430–17437 . 2003 . 12621057 . 10.1074/jbc.M301569200 . free.
• Martín M, Del Valle JM, Saborit I, Engel P . Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229 . J. Immunol. . 174 . 10 . 5977–86 . 2005 . 15879090 . 10.4049/jimmunol.174.10.5977 . free .
• Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P . CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse . J. Immunol. . 174 . 11 . 7033–42 . 2005 . 15905546 . 10.4049/jimmunol.174.11.7033 . free .

Notes and References

1. Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF . Grant Robert Sutherland . Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9 . Immunogenetics . 43 . 1–2 . 13–9 . Feb 1996 . 8537117 . 10.1007/bf00186599 . 10045488 .
2. Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF . Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1 . Immunogenetics . 42 . 1 . 59–62 . Aug 1995 . 7797269 . 10.1007/BF00164988 . 28529549 .
3. Web site: Entrez Gene: LY9 lymphocyte antigen 9.
4. Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C . Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP . Blood . 97 . 12 . 3867–3874 . Jun 2001 . 11389028 . 10.1182/blood.V97.12.3867 . free .
5. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C . Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients . J. Biol. Chem. . 276 . 39 . 36809–36816 . Sep 2001 . 11477068 . 10.1074/jbc.M101305200 . 39889619 . free .