LY6G6E explained

Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene.^[1]

Function

LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction.^[2]

Further reading

• Mallya M, Campbell RD, Aguado B . Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands . Protein Science . 15 . 10 . 2244–56 . October 2006 . 17008713 . 2242401 . 10.1110/ps.062242606 .
• Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD . Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region . Journal of Immunology . 163 . 1 . 278–87 . July 1999 . 10.4049/jimmunol.163.1.278 . 10384126 .
• Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG . Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci . Arthritis and Rheumatism . 60 . 1 . 53–62 . January 2009 . 19116923 . 10.1002/art.24138 . free .
• Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium . Nature . 401 . 6756 . 921–3 . October 1999 . 10553908 . 10.1038/44853 . 186243515 .

Notes and References

1. Web site: Entrez Gene: Lymphocyte antigen 6 complex, locus G6E pseudogene) .
2. Mallya M, Campbell RD, Aguado B . Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms . Genomics . 80 . 1 . 113–23 . July 2002 . 12079290 . 10.1006/geno.2002.6794 .