LY6E explained

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^{[1] [2] [3]} Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.^[4] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.^[5] Further research is required to validate Ly6E for translation research. http://www.telmarc.com/Documents/White%20Papers/133LY6.pdf

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Brakenhoff RH, van Dijk M, Rood-Knippels EM, Snow GB . A gain of novel tissue specificity in the human Ly-6 gene E48 . J. Immunol. . 159 . 10 . 4879–86 . 1997 . 10.4049/jimmunol.159.10.4879 . 9366413 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Shan X, Bourdeau A, Rhoton A, Wells DE, Cohen EH, Landgraf BE, Palfree RG . Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1 . J. Immunol. . 160 . 1 . 197–208 . 1998 . 10.4049/jimmunol.160.1.197 . 9551972 . free .
• Kosugi A, Saitoh S, Noda S, Miyake K, Yamashita Y, Kimoto M, Ogata M, Hamaoka T . Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex . J. Biol. Chem. . 273 . 20 . 12301–6 . 1998 . 9575182 . 10.1074/jbc.273.20.12301 . free .
• Ding L, Shevach EM . Inhibition of the function of the FcγRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen . Immunology . 104 . 1 . 28–36 . 2001 . 11576217 . 1783287 . 10.1046/j.1365-2567.2001.01275.x .
• Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ . Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland . Mol. Cell. Biol. . 22 . 3 . 946–52 . 2002 . 11784869 . 133557 . 10.1128/MCB.22.3.946-952.2002 .
• de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB, Brakenhoff RH . Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma . Int. J. Cancer . 103 . 6 . 768–74 . 2003 . 12516096 . 10.1002/ijc.10903 . 42182637 .

Notes and References

1. Capone MC, Gorman DM, Ching EP, Zlotnik A . Identification through bioinformatics of cDNAs encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family . J Immunol . 157 . 3 . 969–73 . Sep 1996 . 10.4049/jimmunol.157.3.969 . 8757598 . free .
2. Mao M, Yu M, Tong JH, Ye J, Zhu J, Huang QH, Fu G, Yu L, Zhao SY, Waxman S, Lanotte M, Wang ZY, Tan JZ, Chan SJ, Chen Z . RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell . Proc Natl Acad Sci U S A . 93 . 12 . 5910–4 . Jul 1996 . 8650192 . 39161 . 10.1073/pnas.93.12.5910 . free . 1996PNAS...93.5910M .
3. Web site: Entrez Gene: LY6E lymphocyte antigen 6 complex, locus E.
4. Luo. Linlin. McGarvey. Peter. Madhavan. Subha. Kumar. Rakesh. Gusev. Yuriy. Upadhyay. Geeta. 2016-02-03. Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. Oncotarget. 10.18632/oncotarget.7163. 1949-2553. 26862846. 7. 10. 4905465. 11165–93.
5. Hossiny. Midrar A.. Luo. Linlin. Frazier. William R.. Steiner. Noriko. Gusev. Yuriy. Kallakury. Bhaskar. Glasgow. Eric. Creswell. Karen. Madhavan. Subha. Kumar. Rakesh. Upadhyay. Geeta. 2016-04-11. Ly6E/K signaling to TGF-β promotes breast cancer progression, immune escape and drug resistance. Cancer Research. en. 3376–3386. 10.1158/0008-5472.CAN-15-2654. 27197181. 4910623. 0008-5472. 76. 11.