LY-307,452 explained

LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3),[1] and was useful in early studies of this receptor family,[2] [3] although it has largely been replaced by newer drugs such as LY-341,495. Its molecular formula is C21H25NO4[4]

Notes and References

  1. Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD . (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase . Journal of Medicinal Chemistry . 39 . 4 . 814–6 . February 1996 . 8632404 . 10.1021/jm9508144 .
  2. Li XC, Beart PM, Monn JA, Jones NM, Widdop RE . Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats . . 128 . 3 . 823–9 . October 1999 . 10516668 . 1571690 . 10.1038/sj.bjp.0702850 .
  3. Sung KW, Choi S, Lovinger DM . Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses . Journal of Neurophysiology . 86 . 5 . 2405–12 . November 2001 . 11698530 . 10.1152/jn.2001.86.5.2405 . 15299425 .
  4. Web site: LY-307,452 | C21H25NO4 | ChemSpider.

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