LY-235959 explained

LY-235959 is a competitive antagonist at the NMDA receptor.^[1] It has analgesic and neuroprotective effects and causes hypothermia in animal models,^[2] as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.^{[3] [4] [5] [6] [7]}

Notes and References

1. Allen RM, Dykstra LA . N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys . The Journal of Pharmacology and Experimental Therapeutics . 298 . 1 . 288–97 . July 2001 . 11408554 .
2. Rawls SM, Cowan A, Tallarida RJ, Geller EB, Adler MW . N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia . The Journal of Pharmacology and Experimental Therapeutics . 303 . 1 . 395–402 . October 2002 . 12235276 . 10.1124/jpet.102.037473 . 18307764 .
3. Allen RM, Carelli RM, Dykstra LA, Suchey TL, Everett CV . Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement . The Journal of Pharmacology and Experimental Therapeutics . 315 . 1 . 449–57 . October 2005 . 16024734 . 10.1124/jpet.105.086355 . 15151429 .
4. Allen RM, Dykstra LA, Carelli RM . Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats . Psychopharmacology . 191 . 2 . 341–51 . April 2007 . 17225167 . 10.1007/s00213-006-0661-3 . 20887004 .
5. Fischer BD, Ward SJ, Henry FE, Dykstra LA . Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects . Neuropharmacology . 58 . 2 . 544–50 . February 2010 . 19699755 . 2813317 . 10.1016/j.neuropharm.2009.08.005 .
6. Dykstra LA, Fischer BD, Balter RE, Henry FE, Schmidt KT, Miller LL . Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice . Behavioural Pharmacology . 22 . 5–6 . 540–7 . September 2011 . 21712708 . 3155647 . 10.1097/FBP.0b013e328348ed08 .
7. Bicca MA, Figueiredo CP, Piermartiri TC, Meotti FC, Bouzon ZL, Tasca CI, Medeiros R, Calixto JB . 6 . The selective and competitive N-methyl-D-aspartate receptor antagonist, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice . Neuroscience . 192 . 631–41 . September 2011 . 21756976 . 10.1016/j.neuroscience.2011.06.038 . 36154501 .