LUC7L3 explained

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.^[1]

This gene encodes a cisplatin resistance-associated overexpressed protein (CROP). The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Nishii Y, Morishima M, Kakehi Y . CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. . FEBS Lett. . 465 . 2–3 . 153–6 . 2000 . 10631324 . 10.1016/S0014-5793(99)01744-5 . 7918526 . etal. free .
• Chin LS, Singh SK, Wang Q, Murray SF . Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells. . J. Biomed. Sci. . 7 . 2 . 152–9 . 2000 . 10754390 . 10.1007/BF02256622 .
• Harrington JJ, Sherf B, Rundlett S . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Umehara H, Nishii Y, Morishima M . Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. . Biochem. Biophys. Res. Commun. . 301 . 2 . 324–9 . 2003 . 12565863 . 10.1016/S0006-291X(02)03017-6 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Jin J, Smith FD, Stark C . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . etal. free . 2004CBio...14.1436J .
• Brown V, Brown RA, Ozinsky A . Binding specificity of Toll-like receptor cytoplasmic domains. . Eur. J. Immunol. . 36 . 3 . 742–53 . 2006 . 16482509 . 10.1002/eji.200535158 . 2762736 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Puig O, Bragado-Nilsson E, Koski T, Séraphin B . The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human. . Nucleic Acids Res. . 35 . 17 . 5874–85 . 2007 . 17726058 . 10.1093/nar/gkm505 . 2034479 .

Notes and References

1. Web site: Entrez Gene: CROP cisplatin resistance-associated overexpressed protein.