LTBP1 (gene) explained

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.^{[1] [2] [3]}

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

Interactions

LTBP1 (gene) has been shown to interact with TGF beta 1.^[4]

Further reading

• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J . Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action . Cytokine Growth Factor Rev. . 10 . 2 . 99–117 . 2000 . 10743502 . 10.1016/S1359-6101(99)00010-6 .
• Keski-Oja J, Koli K, von Melchner H . TGF-beta activation by traction? . Trends Cell Biol. . 14 . 12 . 657–659 . 2005 . 15564041 . 10.1016/j.tcb.2004.10.003 .
• Stenman G . Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12→q22 . Cytogenet. Cell Genet. . 66 . 2 . 117–119 . 1994 . 8287682 . 10.1159/000133680 . vanc. Sahlin P . Olofsson A . 3 . Van Kessel . Geurts . Miyazono . K. .
• Olofsson A . Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix . J. Biol. Chem. . 270 . 52 . 31294–31297 . 1996 . 8537398 . 10.1074/jbc.270.52.31294 . vanc. Ichijo H . Morén A . 3 . Ten Dijke . P . Miyazono . K . Heldin . CH . free .
• Saharinen J, Taipale J, Keski-Oja J . Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1 . EMBO J. . 15 . 2 . 245–53 . 1996 . 8617200 . 10.1002/j.1460-2075.1996.tb00355.x. 449939 .
• Taipale J, Saharinen J, Hedman K, Keski-Oja J . Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils . J. Histochem. Cytochem. . 44 . 8 . 875–89 . 1996 . 8756760 . 10.1177/44.8.8756760 . free .
• Nunes I, Gleizes PE, Metz CN, Rifkin DB . Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta . J. Cell Biol. . 136 . 5 . 1151–1163 . 1997 . 9060478 . 10.1083/jcb.136.5.1151 . 2132473 .
• Karonen T, Jeskanen L, Keski-Oja J . Transforming growth factor beta 1 and its latent form binding protein-1 associate with elastic fibres in human dermis: accumulation in actinic damage and absence in anetoderma . Br. J. Dermatol. . 137 . 1 . 51–58 . 1997 . 9274625 . 10.1111/j.1365-2133.1997.tb03700.x .
• Dallas SL . Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo . J. Bone Miner. Res. . 15 . 1 . 68–81 . 2000 . 10646116 . 10.1359/jbmr.2000.15.1.68 . vanc. Keene DR . Bruder SP . 3 . Saharinen . Juha . Sakai . Lynn Y. . Mundy . Gregory R. . Bonewald . Lynda F. . 10766165 . free .
• Saharinen J, Keski-Oja J . Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta . Mol. Biol. Cell . 11 . 8 . 2691–704 . 2000 . 10930463 . 10.1091/mbc.11.8.2691. 14949 .
• Ludbrook SB, Barry ST, Delves CJ, Horgan CM . The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 . Biochem. J. . 369 . Pt 2 . 311–8 . 2003 . 12358597 . 10.1042/BJ20020809 . 1223078 .
• Isogai Z . Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein . J. Biol. Chem. . 278 . 4 . 2750–2757 . 2003 . 12429738 . 10.1074/jbc.M209256200 . vanc. Ono RN . Ushiro S . 3 . Keene . DR . Chen . Y . Mazzieri . R . Charbonneau . NL . Reinhardt . DP . Rifkin . DB . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Gui Y, Murphy LJ . Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1 . Mol. Cell. Biochem. . 250 . 1–2 . 189–195 . 2004 . 12962157 . 10.1023/A:1024990409102 . 6372795 .
• Weikkolainen K, Keski-Oja J, Koli K . Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts . Growth Factors . 21 . 2 . 51–60 . 2004 . 14626352 . 10.1080/08977198310001598778 . 42812652 .
• Shariat SF . Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression . Clin. Cancer Res. . 10 . 6 . 1992–1999 . 2004 . 15041717 . 10.1158/1078-0432.CCR-0768-03 . vanc. Kattan MW . Traxel E . 3 . Andrews . B . Zhu . K . Wheeler . TM . Slawin . KM . free .

Notes and References

1. Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH . TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences . Cell . 61 . 6 . 1051–1061 . July 1990 . 2350783 . 10.1016/0092-8674(90)90069-Q . 54376541 .
2. Oklu R, Hesketh R . The latent transforming growth factor beta binding protein (LTBP) family . Biochem J . 352 . 3. 601–10 . January 2001 . 11104663 . 1221494 . 10.1042/0264-6021:3520601.
3. Web site: Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1.
4. Saharinen . J . Keski-Oja J . August 2000 . Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta . Mol. Biol. Cell . 11 . 8 . 2691–704 . 1059-1524. 10930463 . 14949 . 10.1091/mbc.11.8.2691.