LSU rRNA explained

Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome.Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.

Symbol:	LSU
Rfam Clan:	CL00112

Characteristics

Characteristics of the LSU rRNA for exemplary species.!Type!LSU rRNA size!Species!Length!Accession!Reference

Bacterial (Prokaryotic)	23S	Escherichia coli	2,905 nt	NR_076322.1	^[1]
Archaeal (Prokaryotic)	23S	Halobacterium salinarum	2,906 nt	NR_076247.1	^[2]
Eukaryotic	5.8S & 28S	Homo sapiens	157 + 5,025 nt	NR_145821.1; M11167.1	^[3] ^[4]
Mitochondrial	16S	Homo sapiens	1,559 nt	NC_012920.1	^[5] ^[6]
Plastid	23S	Arabidopsis thaliana	2,810 nt	NC_000932.1	^[7]

Use in phylogenetics

LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.

See also

• SSU rRNA

the small subunit ribosomal ribonucleic acid.

Notes and References

1. Web site: Escherichia coli 23S ribosomal RNA . 3 February 2015 .
2. Web site: Halobacterium salinarum 23S ribosomal RNA . 3 February 2015 .
3. Web site: Homo sapiens RNA, 5.8S ribosomal N1 (RNA5-8SN1), ribosomal RNA . 3 July 2020.
4. Web site: Homo sapiens 28S ribosomal RNA (nuclear) . 10 November 1986 .
5. Homo sapiens mitochondrion, complete genome. "Revised Cambridge Reference Sequence (rCRS): accession NC_012920", National Center for Biotechnology Information. Retrieved on 20 February 2017.
6. Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG . Sequence and organization of the human mitochondrial genome . Nature . 290 . 5806 . 457–465 . April 1981 . 7219534 . 10.1038/290457a0 . 1981Natur.290..457A .
7. Web site: Arabidopsis thaliana 23S ribosomal RNA (chloroplast) . 3 April 2023 .