LST1 explained

Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the LST1 gene.^{[1] [2] [3]}

Further reading

• Abraham LJ, Grimsley G, Zhang WJ, etal . Polymorphism in the human B144 gene in different MHC haplotypes. . Eur. J. Immunogenet. . 19 . 3 . 165–8 . 1992 . 1352700 . 10.1111/j.1744-313X.1992.tb00055.x . 28280986 .
• Holzinger I, de Baey A, Messer G, etal . Cloning and genomic characterization of LST1: a new gene in the human TNF region. . Immunogenetics . 42 . 5 . 315–22 . 1995 . 7590964 . 10.1007/BF00179392. 19916860 .
• Pende D, Parolini S, Pessino A, etal . Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells . J. Exp. Med. . 190 . 10 . 1505–16 . 1999 . 10562324 . 10.1084/jem.190.10.1505. 2195691 .
• Neville MJ, Campbell RD . Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6 . DNA Seq. . 8 . 3 . 155–60 . 2000 . 10668961 . 10.3109/10425179709034067 .
• Rollinger-Holzinger I, Eibl B, Pauly M, etal . LST1: a gene with extensive alternative splicing and immunomodulatory function . J. Immunol. . 164 . 6 . 3169–76 . 2000 . 10706707 . 10.4049/jimmunol.164.6.3169. free .
• Yu X, Weissman SM . Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts . J. Biol. Chem. . 275 . 44 . 34597–608 . 2000 . 10944527 . 10.1074/jbc.M004700200 . free .
• Raghunathan A, Sivakamasundari R, Wolenski J, etal . Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells . Exp. Cell Res. . 268 . 2 . 230–44 . 2001 . 11478849 . 10.1006/excr.2001.5290 .
• Ferlazzo G, Tsang ML, Moretta L, etal . Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells . J. Exp. Med. . 195 . 3 . 343–51 . 2002 . 11828009 . 10.1084/jem.20011149. 2193591 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Castriconi R, Cantoni C, Della Chiesa M, etal . Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells . Proc. Natl. Acad. Sci. U.S.A. . 100 . 7 . 4120–5 . 2003 . 12646700 . 10.1073/pnas.0730640100 . 153058 . 2003PNAS..100.4120C . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Xie T, Rowen L, Aguado B, etal . Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse . Genome Res. . 13 . 12 . 2621–36 . 2004 . 14656967 . 10.1101/gr.1736803 . 403804 .
• Lehner B, Semple JI, Brown SE, etal . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Harrison RE, Sikorski BA, Jongstra J . Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton . J. Cell Sci. . 117 . Pt 10 . 2151–7 . 2005 . 15090600 . 10.1242/jcs.00955 . free .
• Marafioti T, Mancini C, Ascani S, etal . Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease . Haematologica . 89 . 8 . 957–64 . 2006 . 15339679 .
• Mulcahy H, O'Rourke KP, Adams C, etal . LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection . Immunogenetics . 57 . 12 . 893–903 . 2006 . 16362817 . 10.1007/s00251-005-0057-2 . 1615261 .

Notes and References

1. Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM . Genes in a 220-kb region spanning the TNF cluster in human MHC . Genomics . 31 . 2 . 215–22 . Mar 1997 . 8824804 . 10.1006/geno.1996.0034 . free .
2. de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH . Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing . Genomics . 45 . 3 . 591–600 . Jan 1998 . 9367684 . 10.1006/geno.1997.4963 .
3. Web site: Entrez Gene: LST1 leukocyte specific transcript 1.