LSM8 explained

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.^{[1] [2]}

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.^[2]

Interactions

LSM8 has been shown to interact with LSM2.^{[3] [4]}

Further reading

• Khusial P, Plaag R, Zieve GW . LSm proteins form heptameric rings that bind to RNA via repeating motifs. . Trends Biochem. Sci. . 30 . 9 . 522–8 . 2005 . 16051491 . 10.1016/j.tibs.2005.07.006 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B . Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. . EMBO J. . 18 . 12 . 3451–62 . 1999 . 10369684 . 10.1093/emboj/18.12.3451 . 1171424 .
• Eystathioy T, Peebles CL, Hamel JC, etal . Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. . Arthritis Rheum. . 46 . 3 . 726–34 . 2002 . 11920408 . 10.1002/art.10220 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
• Lehner B, Semple JI, Brown SE, etal . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R . A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro . EMBO J . 18 . 20 . 5789–802 . Dec 1999 . 10523320 . 1171645 . 10.1093/emboj/18.20.5789 .
2. Web site: Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae).
3. Lehner . Ben . Sanderson Christopher M . Jul 2004 . A protein interaction framework for human mRNA degradation . Genome Res. . 14 . 7 . 1315–23 . 1088-9051. 15231747 . 10.1101/gr.2122004 . 442147 .
4. 10.1016/S0888-7543(03)00235-0 . Lehner . Ben . Semple Jennifer I . Brown Stephanie E . Counsell Damian . Campbell R Duncan . Sanderson Christopher M . Jan 2004 . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 0888-7543. 14667819 .