LSM7 explained

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.^{[1] [2]}

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[3]

Interactions

LSM7 has been shown to interact with TACC1^{[4] [5]} and LSM2.^{[6] [7]}

Further reading

• Friesen WJ, Dreyfuss G . Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) . The Journal of Biological Chemistry . 275 . 34 . 26370–5 . Aug 2000 . 10851237 . 10.1074/jbc.M003299200 . free .
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y . Protein-protein interaction panel using mouse full-length cDNAs . Genome Research . 11 . 10 . 1758–65 . Oct 2001 . 11591653 . 311163 . 10.1101/gr.180101 .
• Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK . Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera . Arthritis and Rheumatism . 46 . 3 . 726–34 . Mar 2002 . 11920408 . 10.1002/art.10220 . free .
• Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D . Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators . Oncogene . 21 . 36 . 5619–30 . Aug 2002 . 12165861 . 10.1038/sj.onc.1205658 . free .
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . Nov 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . Jan 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Stanĕk D, Neugebauer KM . Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer . The Journal of Cell Biology . 166 . 7 . 1015–25 . Sep 2004 . 15452143 . 2172029 . 10.1083/jcb.200405160 .

Notes and References

1. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R . A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro . The EMBO Journal . 18 . 20 . 5789–802 . Oct 1999 . 10523320 . 1171645 . 10.1093/emboj/18.20.5789 .
2. Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T . The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci . RNA . 8 . 12 . 1489–501 . Dec 2002 . 12515382 . 1370355 . 10.1017/S1355838202021726.
3. Web site: Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae).
4. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D . TACC1-chTOG-Aurora A protein complex in breast cancer . Oncogene . 22 . 50 . 8102–16 . Nov 2003 . 14603251 . 10.1038/sj.onc.1206972 . 10536264 .
5. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D . Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators . Oncogene . 21 . 36 . 5619–30 . Aug 2002 . 12165861 . 10.1038/sj.onc.1205658 . free .
6. Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
7. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . Jan 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .