LSM5 explained

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.^{[1] [2] [3]}

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]

Further reading

• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Eystathioy T . Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera . Arthritis Rheum. . 46 . 3 . 726–34 . 2002 . 11920408 . 10.1002/art.10220 . vanc. Peebles CL . Hamel JC . 3 . Vaughn . John H. . Chan . Edward K. L. . free .
• Suzuki H . Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 10.1101/gr.180101 . 311163 . vanc. Fukunishi Y . Kagawa I . 3 . Saito . R . Oda . H . Endo . T . Kondo . S . Bono . H . Okazaki . Y .
• Friesen WJ, Dreyfuss G . Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) . J. Biol. Chem. . 275 . 34 . 26370–5 . 2000 . 10851237 . 10.1074/jbc.M003299200 . free .
• Achsel T . A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro . EMBO J. . 18 . 20 . 5789–802 . 1999 . 10523320 . 10.1093/emboj/18.20.5789 . 1171645 . vanc. Brahms H . Kastner B . 3 . Bachi . A . Wilm . M . Lührmann . R .

Notes and References

1. Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B . Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin . EMBO J . 18 . 12 . 3451–62 . Aug 1999 . 10369684 . 1171424 . 10.1093/emboj/18.12.3451 .
2. Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T . The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci . RNA . 8 . 12 . 1489–501 . Jan 2003 . 12515382 . 1370355 . 10.1017/S1355838202021726.
3. Web site: Entrez Gene: LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae).