LSM1 explained

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.^{[1] [2] [3]}

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.

Further reading

• Shimizu Y . Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells . Am. J. Hematol. . 54 . 1 . 1–11 . 1997 . 8980254 . 10.1002/(SICI)1096-8652(199701)54:1<1::AID-AJH1>3.0.CO;2-1 . vanc. Sugiyama H . Fujii Y . 3 . Sasaki . K. . Inoue . K. . Ogawa . H. . Tamaki . H. . Miyake . S. . Oji . Y. . free .
• Schweinfest CW . CaSm: an Sm-like protein that contributes to the transformed state in cancer cells . Cancer Res. . 57 . 14 . 2961–5 . 1997 . 9230209 . vanc. Graber MW . Chapman JM . 3 . Papas . TS . Baron . PL . Watson . DK .
• Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B . Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin . EMBO J. . 18 . 12 . 3451–62 . 1999 . 10369684 . 10.1093/emboj/18.12.3451 . 1171424 .
• Achsel T . A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro . EMBO J. . 18 . 20 . 5789–802 . 1999 . 10523320 . 10.1093/emboj/18.20.5789 . 1171645 . vanc. Brahms H . Kastner B . 3 . Bachi . A . Wilm . M . Lührmann . R .
• Friesen WJ, Dreyfuss G . Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) . J. Biol. Chem. . 275 . 34 . 26370–5 . 2000 . 10851237 . 10.1074/jbc.M003299200 . free .
• Eystathioy T . Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera . Arthritis Rheum. . 46 . 3 . 726–34 . 2002 . 11920408 . 10.1002/art.10220 . vanc. Peebles CL . Hamel JC . 3 . Vaughn . John H. . Chan . Edward K. L. . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lehner B . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . vanc. Semple JI . Brown SE . 3 . Counsell . Damian . Campbell . R.Duncan . Sanderson . Christopher M .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Wichroski MJ, Robb GB, Rana TM . Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies . PLOS Pathog. . 2 . 5 . e41 . 2006 . 16699599 . 10.1371/journal.ppat.0020041 . 1458959 . free .
• Chu CY, Rana TM . Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54 . PLOS Biol. . 4 . 7 . e210 . 2006 . 16756390 . 10.1371/journal.pbio.0040210 . 1475773 . free .
• Streicher KL, Yang ZQ, Draghici S, Ethier SP . Transforming function of the LSM1 oncogene in human breast cancers with the 8p11−12 amplicon . Oncogene . 26 . 14 . 2104–14 . 2007 . 17001308 . 10.1038/sj.onc.1210002 . 2435249 .

Notes and References

1. Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T . The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci . RNA . 8 . 12 . 1489–501 . Jan 2003 . 12515382 . 1370355 . 10.1017/S1355838202021726 .
2. Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T . Down-regulation of Lsm1 is involved in human prostate cancer progression . Br J Cancer . 86 . 6 . 940–6 . Apr 2002 . 11953827 . 2364150 . 10.1038/sj.bjc.6600163 .
3. Web site: Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae).