LRRK1 explained

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.^{[1] [2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Korr D, Toschi L, Donner P, etal . LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. . Cell. Signal. . 18 . 6 . 910–20 . 2006 . 16243488 . 10.1016/j.cellsig.2005.08.015 .
• Zody MC, Garber M, Sharpe T, etal . Analysis of the DNA sequence and duplication history of human chromosome 15. . Nature . 440 . 7084 . 671–5 . 2006 . 16572171 . 10.1038/nature04601 . 2006Natur.440..671Z . free .
• Haugarvoll K, Toft M, Ross OA, etal . Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. . Neurosci. Lett. . 416 . 3 . 299–301 . 2007 . 17324517 . 10.1016/j.neulet.2007.02.020 . 10196943 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Greggio E, Lewis PA, van der Brug MP, etal . Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. . J. Neurochem. . 102 . 1 . 93–102 . 2007 . 17394548 . 10.1111/j.1471-4159.2007.04523.x . free .

Notes and References

1. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 8 . 2 . 85–95 . May 2001 . 11347906 . 10.1093/dnares/8.2.85 . free .
2. Bosgraaf L, Van Haastert PJ . Roc, a Ras/GTPase domain in complex proteins . Biochim Biophys Acta . 1643 . 1–3 . 5–10 . Dec 2003 . 14654223 . 10.1016/j.bbamcr.2003.08.008 . 45525061 .
3. Web site: Entrez Gene: LRRK1 leucine-rich repeat kinase 1.