LRRC4 explained

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.^{[1] [2]}

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nakashiba T, Ikeda T, Nishimura S, etal . Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. . J. Neurosci. . 20 . 17 . 6540–50 . 2000 . 10964959 . 6772945 . 10.1523/JNEUROSCI.20-17-06540.2000. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Lin JC, Ho WH, Gurney A, Rosenthal A . The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. . Nat. Neurosci. . 6 . 12 . 1270–6 . 2004 . 14595443 . 10.1038/nn1148 . 28353131 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Zhang Q, Wang J, Fan S, etal . Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. . FEBS Lett. . 579 . 17 . 3674–82 . 2005 . 15967442 . 10.1016/j.febslet.2005.05.058 . 19888187 .
• Zhang QH, Wang LL, Cao L, etal . Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. . Acta Biochim. Biophys. Sin. (Shanghai) . 37 . 8 . 532–40 . 2005 . 16077900 . 10.1111/j.1745-7270.2005.00079.x . free .
• Fan SQ, Wang JR, Huang H, etal . [Function of a novel brain-specific gene LRRC4] . Zhonghua Zhong Liu Za Zhi . 27 . 7 . 393–6 . 2007 . 16188120 .
• Zhang QH, Wu MH, Wang LL, etal . Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array. . Acta Biochim. Biophys. Sin. (Shanghai) . 37 . 10 . 680–7 . 2005 . 16215635 . 10.1111/j.1745-7270.2005.00100.x . free .
• Wu M, Huang C, Gan K, etal . LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. . Mol. Biol. Cell . 17 . 8 . 3534–42 . 2006 . 16723503 . 10.1091/mbc.E05-11-1082 . 1525233 .
• Wu M, Gan K, Huang C, etal . LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. . J. Neurooncol. . 80 . 2 . 133–42 . 2007 . 16941076 . 10.1007/s11060-006-9173-6 . 30590797 .
• Wu M, Huang C, Li X, etal . LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. . J. Cell. Physiol. . 214 . 1 . 65–74 . 2007 . 17541939 . 10.1002/jcp.21163 . 44665033 .

External links

• • Role of LRRC4 in Rosacea

Notes and References

1. Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY . Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251 . AI Zheng . 22 . 9 . 897–902 . Sep 2003 . 12969517 .
2. Web site: Entrez Gene: LRRC4 leucine rich repeat containing 4.
3. Deng Z, Chen M, Zhao Z, etal . Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea . Nature Communications . 14 . 3958 . 2023 . 3958 . 10.1038/s41467-023-39761-2 . free. 37402769 . 10319783 . 2023NatCo..14.3958D .