LRP1B explained

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.^{[1] [2]}

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.^[3]

Further reading

• Liu CX, Musco S, Lisitsina NM, etal . Genomic organization of a new candidate tumor suppressor gene, LRP1B . Genomics . 69 . 2 . 271–4 . 2001 . 11031110 . 10.1006/geno.2000.6331 .
• Langbein S, Szakacs O, Wilhelm M, etal . Alteration of the LRP1B gene region is associated with high grade of urothelial cancer . Lab. Invest. . 82 . 5 . 639–43 . 2002 . 12004004 . 10.1038/labinvest.3780458 . free .
• Li Y, Knisely JM, Lu W, etal . Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration . J. Biol. Chem. . 277 . 44 . 42366–71 . 2003 . 12194987 . 10.1074/jbc.M207705200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Cam JA, Zerbinatti CV, Knisely JM, etal . The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production . J. Biol. Chem. . 279 . 28 . 29639–46 . 2004 . 15126508 . 10.1074/jbc.M313893200 . free .
• Tanaga K, Bujo H, Zhu Y, etal . LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors . Arterioscler. Thromb. Vasc. Biol. . 24 . 8 . 1422–8 . 2005 . 15166012 . 10.1161/01.ATV.0000133607.80554.09 . free .
• Sonoda I, Imoto I, Inoue J, etal . Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma . Cancer Res. . 64 . 11 . 3741–7 . 2004 . 15172977 . 10.1158/0008-5472.CAN-04-0172 . 12527714 .
• Li Y, Lu W, Bu G . Striking differences of LDL receptor-related protein 1B expression in mouse and human . Biochem. Biophys. Res. Commun. . 333 . 3 . 868–73 . 2005 . 15963947 . 10.1016/j.bbrc.2005.05.170 .
• Pastrana DV, Hanson AJ, Knisely J, etal . LRP 1 B functions as a receptor for Pseudomonas exotoxin . Biochim. Biophys. Acta . 1741 . 3 . 234–9 . 2006 . 16095885 . 10.1016/j.bbadis.2005.06.007 . free .
• Nakagawa T, Pimkhaokham A, Suzuki E, etal . Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma . Cancer Sci. . 97 . 10 . 1070–4 . 2006 . 16918994 . 10.1111/j.1349-7006.2006.00283.x . 30699151 . 11159176 .
• Liu CX, Ranganathan S, Robinson S, Strickland DK . gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells . J. Biol. Chem. . 282 . 10 . 7504–11 . 2007 . 17227771 . 10.1074/jbc.M608088200 . free .

Notes and References

1. Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA . LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines . Cancer Res . 60 . 7 . 1961–7 . May 2000 . 10766186 .
2. Web site: Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors).
3. Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G . The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein . J. Biol. Chem. . 276 . 31 . 28889–96 . August 2001 . 11384978 . 10.1074/jbc.M102727200 . free .