LRIG1 explained

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.^{[1] [2] [3]} It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family^[4] and with MET^[5] and RET.^[6]

Further reading

• Suzuki Y . cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains . J. Biol. Chem. . 271 . 37 . 22522–7 . 1996 . 8798419 . 10.1074/jbc.271.37.22522 . vanc. Sato N . Tohyama M . 3 . Wanaka . A . Takagi . T . free.
• Suzuki Y . Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia . FEBS Lett. . 521 . 1–3 . 67–71 . 2002 . 12067728 . 10.1016/S0014-5793(02)02824-7 . vanc. Miura H . Tanemura A . 3 . Kobayashi . K . Kondoh . G . Sano . S . Ozawa . K . Inui . S . Nakata . A . 5634836 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Nilsson J, Starefeldt A, Henriksson R, Hedman H . LRIG1 protein in human cells and tissues . Cell Tissue Res. . 312 . 1 . 65–71 . 2004 . 12684867 . 10.1007/s00441-003-0697-1 . 7060595 .
• Thomasson M . LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis . Br. J. Cancer . 89 . 7 . 1285–9 . 2003 . 14520461 . 10.1038/sj.bjc.6601208 . 2394322 . vanc. Hedman H . Guo D . 3 . Ljungberg . B . Henriksson . R .
• Gur G . LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation . EMBO J. . 23 . 16 . 3270–81 . 2005 . 15282549 . 10.1038/sj.emboj.7600342 . 514515 . vanc. Rubin C . Katz M . 3 . Amit . Ido . Citri . Ami . Nilsson . Jonas . Amariglio . Ninette . Henriksson . Roger . Rechavi . Gideon .
• Laederich MB . The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases . J. Biol. Chem. . 279 . 45 . 47050–6 . 2004 . 15345710 . 10.1074/jbc.M409703200 . vanc. Funes-Duran M . Yen L . 3 . Ingalla . E . Wu . X . Carraway Kl . 3rd . Sweeney . C . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ljuslinder I . Increased copy number at 3p14 in breast cancer . Breast Cancer Res. . 7 . 5 . R719–27 . 2006 . 16168117 . 10.1186/bcr1279 . 1242137 . vanc. Malmer B . Golovleva I . 3 . Thomasson . Marcus . Grankvist . Kjell . Höckenström . Thomas . Emdin . Stefan . Jonsson . Yvonne . Hedman . Håkan . free .
• Jensen KB, Watt FM . Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence . Proc. Natl. Acad. Sci. U.S.A. . 103 . 32 . 11958–63 . 2006 . 16877544 . 10.1073/pnas.0601886103 . 1567680 . 2006PNAS..10311958J . free .
• Shattuck DL . LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy . Mol. Cell. Biol. . 27 . 5 . 1934–46 . 2007 . 17178829 . 10.1128/MCB.00757-06 . 1820466 . vanc. Miller JK . Laederich M . 3 . Funes . M. . Petersen . H. . Carraway . K. L. . Sweeney . C. .

Notes and References

1. Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H . Cloning, characterization, and expression of human LIG1 . Biochem Biophys Res Commun . 284 . 5 . 1155–61 . Jun 2001 . 11414704 . 10.1006/bbrc.2001.5092 .
2. Hedman H, Nilsson J, Guo D, Henriksson R . Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? . Acta Oncol . 41 . 4 . 352–4 . Sep 2002 . 12234026 . 10.1080/028418602760169398 . 34357648 .
3. Web site: Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1.
4. Gur G . LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation . EMBO J. . 23 . 16 . 3270–81 . 2005 . 15282549 . 10.1038/sj.emboj.7600342 . 514515 . vanc. Rubin C . Katz M . 3 . Amit . Ido . Citri . Ami . Nilsson . Jonas . Amariglio . Ninette . Henriksson . Roger . Rechavi . Gideon .
5. Shattuck DL . LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy . Mol. Cell. Biol. . 27 . 5 . 1934–46 . 2007 . 17178829 . 10.1128/MCB.00757-06 . 1820466 . vanc. Miller JK . Laederich M . 3 . Funes . M. . Petersen . H. . Carraway . K. L. . Sweeney . C. .
6. Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G . Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF . J. Neurosci. . 28 . 2 . 39–49 . 2008 . 18171921 . 10.1523/JNEUROSCI.2196-07.2008 . 6671136 . free .