LPXN explained

Leupaxin is a protein that in humans is encoded by the LPXN gene.^{[1] [2]}

The product encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by tyrosine kinase activity.

Further reading

• Chew V, Lam KP . Leupaxin negatively regulates B cell receptor signaling. . J. Biol. Chem. . 282 . 37 . 27181–91 . 2007 . 17640867 . 10.1074/jbc.M704625200 . free .
• Sahu SN, Nunez S, Bai G, Gupta A . Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. . Am. J. Physiol., Cell Physiol. . 292 . 6 . C2288–96 . 2007 . 17329398 . 10.1152/ajpcell.00503.2006 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Tao WA, Wollscheid B, O'Brien R, etal . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Watanabe N, Amano N, Ishizuka H, Mashima K . Leupaxin binds to PEST domain tyrosine phosphatase PEP. . Mol. Cell. Biochem. . 269 . 1–2 . 13–7 . 2005 . 15786712 . 10.1007/s11010-005-2149-6 . 21854825 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Brill LM, Salomon AR, Ficarro SB, etal . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Gupta A, Lee BS, Khadeer MA, etal . Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. . J. Bone Miner. Res. . 18 . 4 . 669–85 . 2003 . 12674328 . 10.1359/jbmr.2003.18.4.669 . 24743841 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Liu S, Thomas SM, Woodside DG, etal . Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. . Nature . 402 . 6762 . 676–81 . 2000 . 10604475 . 10.1038/45264 . 2770368 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Lipsky BP, Beals CR, Staunton DE . Leupaxin is a novel LIM domain protein that forms a complex with PYK2 . J Biol Chem . 273 . 19 . 11709–13 . Jun 1998 . 9565592 . 10.1074/jbc.273.19.11709 . free .
2. Web site: Entrez Gene: LPXN leupaxin.