LPP (gene) explained

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.^{[1] [2]}

Function

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.^[2]

Further reading

• Schoenmakers EF . Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours . Nat. Genet. . 10 . 4 . 436–44 . 1995 . 7670494 . 10.1038/ng0895-436 . vanc. Wanschura S . Mols R . 3 . Bullerdiek . Jörn . Van Den Berghe . Herman . Van De Ven . Wim J.M. . 29935721 .
• Petit MM, Swarts S, Bridge JA, Van de Ven WJ . Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma . Cancer Genet. Cytogenet. . 106 . 1 . 18–23 . 1998 . 9772904 . 10.1016/S0165-4608(98)00038-7 .
• Petit MM . LPP, an Actin Cytoskeleton Protein Related to Zyxin, Harbors a Nuclear Export Signal and Transcriptional Activation Capacity . Mol. Biol. Cell . 11 . 1 . 117–29 . 2000 . 10637295 . 10.1091/mbc.11.1.117. 14761 . vanc. Fradelizi J . Golsteyn RM . 3 . Ayoubi . TA . Menichi . B . Louvard . D . Van De Ven . WJ . Friederich . E .
• Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J . An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15) . Genes Chromosomes Cancer . 29 . 4 . 363–6 . 2001 . 11066083 . 10.1002/1098-2264(2000)9999:9999<1::AID-GCC1043>3.0.CO;2-N . 35883889 .
• Harrington JJ . Creation of genome-wide protein expression libraries using random activation of gene expression . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . vanc. Sherf B . Rundlett S . 3 . Jackson . P. David . Perry . Rob . Cain . Scott . Leventhal . Christina . Thornton . Mark . Ramachandran . Rakesh . 25064683 .
• Dahéron L . Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23) . Genes Chromosomes Cancer . 31 . 4 . 382–9 . 2001 . 11433529 . 10.1002/gcc.1157 . vanc. Veinstein A . Brizard F . 3 . Drabkin . Harry . Lacotte . Laurence . Guilhot . François . Larsen . Christian Jacques . Brizard . André . Roche . Joelle . 32921978 . free .
• Lemke I, Rogalla P, Bullerdiek J . A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas . Cytogenet. Cell Genet. . 95 . 3–4 . 153–6 . 2002 . 12063392 . 10.1159/000059338 . 42951388 .
• Petit MM, Meulemans SM, Van de Ven WJ . The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein . J. Biol. Chem. . 278 . 4 . 2157–68 . 2003 . 12441356 . 10.1074/jbc.M206106200 . free .
• Lemke I . Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas . Cancer Genet. Cytogenet. . 138 . 2 . 160–4 . 2003 . 12505264 . 10.1016/S0165-4608(02)00595-2 . vanc. Rogalla P . Grundmann F . 3 . Kunze . Wolf-Peter . Haupt . Rolf . Bullerdiek . Jörn .
• Salomon AR . Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry . Proc. Natl. Acad. Sci. U.S.A. . 100 . 2 . 443–8 . 2003 . 12522270 . 10.1073/pnas.2436191100 . 141014 . vanc. Ficarro SB . Brill LM . 3 . Brinker . A . Phung . QT . Ericson . C . Sauer . K . Brock . A . Horn . DM . 2003PNAS..100..443S . free .
• Li B, Zhuang L, Reinhard M, Trueb B . The lipoma preferred partner LPP interacts with alpha-actinin . J. Cell Sci. . 116 . Pt 7 . 1359–66 . 2003 . 12615977 . 10.1242/jcs.00309 . free .
• Gorenne I . LPP, a LIM protein highly expressed in smooth muscle . Am. J. Physiol., Cell Physiol. . 285 . 3 . C674–85 . 2003 . 12760907 . 10.1152/ajpcell.00608.2002 . vanc. Nakamoto RK . Phelps CP . 3 . Beckerle . MC . Somlyo . AV . Somlyo . AP .
• Brill LM . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . vanc. Salomon AR . Ficarro SB . 3 . Mukherji . Mridul . Stettler-Gill . Michelle . Peters . Eric C. .
• Rush J . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . vanc. Moritz A . Lee KA . 3 . Guo . Ailan . Goss . Valerie L . Spek . Erik J . Zhang . Hui . Zha . Xiang-Ming . Polakiewicz . Roberto D . 7200157 .
• Petit MM . The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus . BMC Cell Biol. . 6 . 1 . 1 . 2006 . 15649318 . 10.1186/1471-2121-6-1 . 546208 . vanc. Meulemans SM . Alen P . 3 . Ayoubi . Torik AY . Jansen . Erik . Van De Ven . Wim JM . free .
• Zhang Y . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . vanc. Wolf-Yadlin A . Ross PL . 3 . Pappin . DJ . Rush . J . Lauffenburger . DA . White . FM . free .
• Tao WA . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . vanc. Wollscheid B . O'Brien R . 3 . Eng . Jimmy K . Li . Xiao-jun . Bodenmiller . Bernd . Watts . Julian D . Hood . Leroy . Aebersold . Ruedi . 20475874 .
• von Ahsen I, Rogalla P, Bullerdiek J . Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15) . Cancer Genet. Cytogenet. . 163 . 1 . 68–70 . 2006 . 16271958 . 10.1016/j.cancergencyto.2005.02.023 .
• Kubo T . Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene . Biochem. Biophys. Res. Commun. . 340 . 2 . 476–81 . 2006 . 16375854 . 10.1016/j.bbrc.2005.12.042 . vanc. Matsui Y . Goto T . 3 . Yukata . Kiminori . Yasui . Natsuo .

Notes and References

1. Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ . LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family . Genomics . 36 . 1 . 118–29 . Feb 1997 . 8812423 . 10.1006/geno.1996.0432 .
2. Web site: Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma.