LPH-48 explained

Routes Of Administration:Unspecified
Class:Selective serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
Synonyms:LPH48

LPH-48 is a selective serotonin 5-HT2A receptor agonist and psychedelic hallucinogen which is under development for the treatment of alcoholism.[1] [2] [3] Its route of administration has not been specified.

The drug acts as a selective agonist of the serotonin 5-HT2A receptor. It is said to be an analogue of LPH-5 with similar characteristics but with faster metabolism and a shorter duration of action. LPH-5 is a highly selective serotonin 5-HT2A receptor agonist that is under development for major depressive disorder and has shown antidepressant-like effects in animals.[4] [5] [6]

LPH-48 is under development by Lophora. As of May 2024, it is in preclinical research for alcoholism. The chemical structure of LPH-48 does not yet seem to have been disclosed. However, Lophora has patented selective serotonin 5-HT2A receptor agonists for treatment of depression[7] and the company is said to have patent protection for LPH-48. Additionally, the structure of its close analogue LPH-5 is known and this compound is a phenylpiperidine derivative.

See also

External links

Notes and References

  1. Web site: LPH 48 . AdisInsight . 22 May 2024 . 30 October 2024 . LPH 48 is a ligand therapeutic which has a similar pharmacological profile as psilocybin with superior selectivity and shorter duration, being developed by [...] .
  2. Web site: Delving into the Latest Updates on LPH-48 with Synapse . Synapse . 19 September 2024 . 30 October 2024.
  3. Web site: Lophora . Lophora Submits Clinical Trial Authorisation (CTA) Application to the French Medicines Agency (ANSM) for Lead CNS Drug LPH-5 . 31 May 2024 . 30 October 2024 . About LPH-48: LPH-48 is a shorter acting direct analog of LPH-5 with similar optimized characteristics and safety profile, but with a shorter duration of action. LPH-48 is designed as a fast-follower that shows significantly faster metabolism, indicating a shorter duration of action in man. LPH-48 is a representative of the same proprietary compound class as LPH-5 and is therefore endowed with the same optimized characteristics including favorable drug-like properties and a safe pharmacological profile..
  4. M Ro Rsted E, Jensen AA, Smits G, Frydenvang K, Kristensen JL . Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists . Journal of Medicinal Chemistry . 67 . 9 . 7224–7244 . May 2024 . 38648420 . 10.1021/acs.jmedchem.4c00082 . 11089506 .
  5. Web site: LPH 5 . AdisInsight . 7 March 2023 . 30 October 2024.
  6. Jensen AA, Cecchi CR, Hibicke M, Bach AH, Kaadt E, Marcher-Rorsted E, Nichols CD, Elfving B, Kristensen JL . The selective 5-HT2Areceptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents . bioRxiv . Cold Spring Harbor Laboratory . 22 April 2024 . 10.1101/2024.04.19.590212 . free .
  7. WO . 2021/089824 . 5-HT2A agonists for use in treatment of depression . Kristensen JL, Jensen AA, Märcher-Rørsted E, Leth-Petersen S . Lophora ApS . 14 May 2021 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "LPH-48".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.