| LOS40 Music Awards 2021 | |
| Date: | November 12, 2021 |
| Most Wins: | Ed Sheeran (4) |
| Most Nominations: | C. Tangana and Ed Sheeran (4 each) |
The sixteenth edition of LOS40 Music Awards was held at the Velòdrom Illes Balears in Palma de Mallorca, on November 12, 2021.[1] Ed Sheeran was the most-awarded artist at the ceremony, winning a total of four awards for Best Artist, Best Song and Video (for "Bad Habits"), and Best Live Act.
| Hombres G | "Voy a pasármelo bien" | |
| Dani Martín | "No, no vuelve" "Son sueños" | |
| Lola Índigo | "Santería" "La Niña de la Escuela" | |
| Leiva Ximena Sariñana | "Histéricos" | |
| Ed Sheeran | "Bad Habits" "Shivers" | |
| Griff | "One Night" | |
| Pablo Alborán Aitana Álvaro de Luna | "Llueve sobre mojado" | |
| Justin Quiles | "Loco" | |
| Nicki Nicole | "Colocao" | |
| Sebastián Yatra | "Tacones rojos" "Pareja del Año" "Chica Ideal" | |
| Marc Seguí | "Tiroteo (Remix)" | |
| Ana Mena Rocco Hunt | "Un beso de improviso" "A un paso de la luna" | |
| Melendi | "La boca junta" | |
| Aitana | "Berlín" "Mon Amour (Remix)" | |
| Beret | "Desde cero" | |
| Álvaro Soler | "Magia" | |
| Topic A7S | "Breaking Me" "Your Love (9PM)" |
On October 24, 2021, Ed Sheeran announced that he had tested positive for Covid-19 and would be fulfilling all subsequent commitments remotely.[3] The singer completed his quarantine by November 2 and was cleared to resume in-person promotional activities for =,[4] including his appearance at Los40.[5]
Nominees were revealed on October 5, 2021, at an announcement dinner held in Ibiza. C. Tangana and Ed Sheeran were the most-nominated artists overall, as well as in the national and international sections respectively, with four nominations each. Rauw Alejandro and Sebastián Yatra led the Latin nominees with three nominations apiece.[6] Sheeran won all four of his nominations and was the most-nominated artist of the night, while C.Tangana won two of his four. Winners are listed first and highlighted in bold.[5]
| Spain | ||
| Best Act | Best New Act | |
|---|---|---|
|
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| Best Album | Best Song | |
|
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| Best Video | Best Live Act | |
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| Del 40 Al 1 Artist Award | ||
| International | ||
| Best Act | Best New Act | |
| Best Album | Best Song | |
| Best Video | Best Live Act | |
| Best Dance Act | ||
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| Latin | ||
| Best Act | Best New Act | |
| ||
| Best Urban Act | Best Song | |
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| Best Video | ||
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| Golden Music Award | ||
| Hombres G Rafael Nadal | ||