LMO7 explained

LIM domain only protein 7 is a protein that in humans is encoded by the LMO7 gene.^{[1] [2] [3]}

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain. An F-box (FBX) domain is present in alternative splice variants. Members of the LIM protein family carry the LIM domain, a unique cysteine-rich zinc-binding domain. Members of the FBX protein family are involved in protein-protein interactions. The encoded protein may be involved in protein-protein interactions. Multiple alternative splice variants have been described but their full-length sequences have not been determined.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1999 . 10048485 . 10.1093/dnares/5.6.355 . free .
• Rozenblum E, Vahteristo P, Sandberg T, etal . A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes . Hum. Genet. . 110 . 2 . 111–21 . 2002 . 11935316 . 10.1007/s00439-001-0646-6 . 21371347 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Benzinger A, Muster N, Koch HB, etal . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Kim J, Bhinge AA, Morgan XC, Iyer VR . Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment . Nat. Methods . 2 . 1 . 47–53 . 2005 . 15782160 . 10.1038/nmeth726 . 6135437 .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Iwabuchi K, Kaneko T, Kikuyama M . Ionic mechanism of mechano-perception in Characeae . Plant Cell Physiol. . 46 . 11 . 1863–71 . 2006 . 16192285 . 10.1093/pcp/pci204 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Holaska JM, Rais-Bahrami S, Wilson KL . Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes . Hum. Mol. Genet. . 15 . 23 . 3459–72 . 2007 . 17067998 . 10.1093/hmg/ddl423 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Putilina T, Jaworski C, Gentleman S, McDonald B, Kadiri M, Wong P . Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain . Biochem Biophys Res Commun . 252 . 2 . 433–9 . Dec 1998 . 9826547 . 10.1006/bbrc.1998.9656 .
2. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . free . 1999CBio....9.1177C .
3. Web site: Entrez Gene: LMO7 LIM domain 7.