LMO4 explained

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.^[1]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.^[1]

Interactions

LMO4 has been shown to interact with LDB1,^{[2] [3]} RBBP8^{[2] [4]} and BRCA1.^{[2] [4]}

Further reading

• Kenny DA, Jurata LW, Saga Y, Gill GN . Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 19 . 11257–62 . 1998 . 9736723 . 10.1073/pnas.95.19.11257 . 21629 . 1998PNAS...9511257K . free .
• Racevskis J, Dill A, Sparano JA, Ruan H . Molecular cloning of LMO41, a new human LIM domain gene. . Biochim. Biophys. Acta . 1445 . 1 . 148–53 . 1999 . 10209267 . 10.1016/s0167-4781(99)00037-8.
• Tse E, Grutz G, Garner AA, etal . Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping. . Mamm. Genome . 10 . 11 . 1089–94 . 2000 . 10556429 . 10.1007/s003359901167 . 19479121 .
• Sum EY, Peng B, Yu X, etal . The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. . J. Biol. Chem. . 277 . 10 . 7849–56 . 2002 . 11751867 . 10.1074/jbc.M110603200 . free .
• Deane JE, Visvader JE, Mackay JP, Matthew JM . 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex. . J. Biomol. NMR . 23 . 2 . 165–6 . 2003 . 12153047 . 10.1023/A:1016363414644 . 30891765 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Vu D, Marin P, Walzer C, etal . Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells. . Brain Res. Mol. Brain Res. . 115 . 2 . 93–103 . 2003 . 12877980 . 10.1016/S0169-328X(03)00119-0 .
• Manetopoulos C, Hansson A, Karlsson J, etal . The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. . Biochem. Biophys. Res. Commun. . 307 . 4 . 891–9 . 2003 . 12878195 . 10.1016/S0006-291X(03)01298-1 .
• Sutherland KD, Visvader JE, Choong DY, etal . Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. . Int. J. Cancer . 107 . 1 . 155–8 . 2003 . 12925972 . 10.1002/ijc.11343 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Novotny-Diermayr V, Lin B, Gu L, Cao X . Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. . J. Biol. Chem. . 280 . 13 . 12747–57 . 2005 . 15677447 . 10.1074/jbc.M500175200 . free .
• Sun T, Patoine C, Abu-Khalil A, etal . Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. . Science . 308 . 5729 . 1794–8 . 2005 . 15894532 . 10.1126/science.1110324 . 2756725 . 2005Sci...308.1794S .
• Sum EY, Segara D, Duscio B, etal . Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 21 . 7659–64 . 2005 . 15897450 . 10.1073/pnas.0502990102 . 1140463 . 2005PNAS..102.7659S . free .
• Jeffries CM, Graham SC, Stokes PH, etal . Stabilization of a binary protein complex by intein-mediated cyclization. . Protein Sci. . 15 . 11 . 2612–8 . 2007 . 17001033 . 10.1110/ps.062377006 . 2242402 .

Notes and References

1. Web site: Entrez Gene: LMO4 LIM domain only 4.
2. Sutherland . Kate D . Visvader Jane E . Choong David Y H . Sum Eleanor Y M . Lindeman Geoffrey J . Campbell Ian G . Oct 2003 . Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas . Int. J. Cancer . 107 . 1 . 155–8 . 0020-7136. 12925972 . 10.1002/ijc.11343 . free .
3. Deane . Janet E . Mackay Joel P . Kwan Ann H Y . Sum Eleanor Y M . Visvader Jane E . Matthews Jacqueline M . May 2003 . Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4 . EMBO J. . 22 . 9 . 2224–33 . 0261-4189. 12727888 . 10.1093/emboj/cdg196 . 156068 .
4. Sum . Eleanor Y M . Peng Benjamin . Yu Xin . Chen Junjie . Byrne Jennifer . Lindeman Geoffrey J . Visvader Jane E . Mar 2002 . The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity . J. Biol. Chem. . 277 . 10 . 7849–56 . 0021-9258. 11751867 . 10.1074/jbc.M110603200 . free .