LMO3 explained

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.^{[1] [2]} LMO3 interacts with the tumor suppressor p53 and regulates its function.^[3] LMO3 is considered to be an oncogene in Neuroblastoma.^[4]

Further reading

• Friedel S, Saar K, Sauer S, Dempfle A, Walitza S, Renner T, Romanos M, Freitag C, Seitz C, Palmason H, Scherag A, Windemuth-Kieselbach C, Schimmelmann BG, Wewetzer C, Meyer J, Warnke A, Lesch KP, Reinhardt R, Herpertz-Dahlmann B, Linder M, Hinney A, Remschmidt H, Schäfer H, Konrad K, Hübner N, Hebebrand J . Association and linkage of allelic variants of the dopamine transporter gene in ADHD . Molecular Psychiatry . 12 . 10 . 923–33 . October 2007 . 17579611 . 10.1038/sj.mp.4001986 . 8 . free .
• Davis C, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Kennedy JL . Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorder . Neuropsychopharmacology . 32 . 10 . 2199–206 . October 2007 . 17314918 . 10.1038/sj.npp.1301348 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . 8 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . 8 .
• Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A . LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma . Cancer Research . 65 . 11 . 4587–97 . June 2005 . 15930276 . 10.1158/0008-5472.CAN-04-4630 . 8 . free .
• Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, Copeland NG, Rabbitts TH . The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development . Journal of Molecular Biology . 226 . 3 . 747–61 . August 1992 . 1507224 . 10.1016/0022-2836(92)90630-3 . 8 .

Notes and References

1. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A . LMO3 interacts with p53 and inhibits its transcriptional activity . Biochemical and Biophysical Research Communications . 392 . 3 . 252–7 . February 2010 . 19995558 . 10.1016/j.bbrc.2009.12.010 .
2. Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y . Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization . Brain Research . 910 . 1–2 . 29–37 . August 2001 . 11489251 . 10.1016/S0006-8993(01)02393-9 . 43814085 .
3. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A . LMO3 interacts with p53 and inhibits its transcriptional activity . Biochemical and Biophysical Research Communications . 392 . 3 . 252–7 . February 2010 . 19995558 . 10.1016/j.bbrc.2009.12.010 .
4. Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A . LMO3 interacts with p53 and inhibits its transcriptional activity . Biochemical and Biophysical Research Communications . 392 . 3 . 252–7 . February 2010 . 19995558 . 10.1016/j.bbrc.2009.12.010 .