LMO1 explained

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.^{[1] [2] [3]}

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.^[3]

Interactions

LMO1 has been shown to interact with GATA3^{[4] [5]} and TAL1.^{[6] [7]}

Further reading

• Foroni L, Boehm T, White L, etal . The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. . J. Mol. Biol. . 226 . 3 . 747–61 . 1992 . 1507224 . 10.1016/0022-2836(92)90630-3 .
• Boehm T, Spillantini MG, Sofroniew MV, etal . Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. . Oncogene . 6 . 5 . 695–703 . 1991 . 2052354 .
• Chen Q, Cheng JT, Tasi LH, etal . The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. . EMBO J. . 9 . 2 . 415–24 . 1990 . 2303035 . 10.1002/j.1460-2075.1990.tb08126.x. 551682 .
• Boehm T, Greenberg JM, Buluwela L, etal . An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. . EMBO J. . 9 . 3 . 857–68 . 1990 . 2311586 . 10.1002/j.1460-2075.1990.tb08183.x. 551746 .
• McGuire EA, Hockett RD, Pollock KM, etal . The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. . Mol. Cell. Biol. . 9 . 5 . 2124–32 . 1989 . 2501659 . 10.1128/MCB.9.5.2124. 363006 .
• Boehm T, Baer R, Lavenir I, etal . The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. . EMBO J. . 7 . 2 . 385–94 . 1988 . 3259177 . 10.1002/j.1460-2075.1988.tb02825.x. 454331 .
• Wadman I, Li J, Bash RO, etal . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. . EMBO J. . 13 . 20 . 4831–9 . 1994 . 7957052 . 10.1002/j.1460-2075.1994.tb06809.x. 395422 .
• Valge-Archer VE, Osada H, Warren AJ, etal . The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 18 . 8617–21 . 1994 . 8078932 . 10.1073/pnas.91.18.8617 . 44657 . 1994PNAS...91.8617V . free .
• Arber S, Caroni P . Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. . Genes Dev. . 10 . 3 . 289–300 . 1996 . 8595880 . 10.1101/gad.10.3.289 . free .
• Jurata LW, Kenny DA, Gill GN . Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 21 . 11693–8 . 1996 . 8876198 . 10.1073/pnas.93.21.11693 . 38120 . 1996PNAS...9311693J . free .
• Ono Y, Fukuhara N, Yoshie O . Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. . J. Biol. Chem. . 272 . 7 . 4576–81 . 1997 . 9020185 . 10.1074/jbc.272.7.4576 . free .
• Valge-Archer V, Forster A, Rabbitts TH . The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). . Oncogene . 17 . 24 . 3199–202 . 1999 . 9872335 . 10.1038/sj.onc.1202353 . 9835264 .
• Bao J, Talmage DA, Role LW, Gautier J . Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. . Development . 127 . 2 . 425–35 . 2000 . 10.1242/dev.127.2.425 . 10603358 .
• Cichutek A, Brueckmann T, Seipel B, etal . Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). . Cytogenet. Cell Genet. . 93 . 3–4 . 277–83 . 2001 . 11528126 . 10.1159/000056998 . 25807985 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lin YW, Deveney R, Barbara M, etal . OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1 . Cancer Res. . 65 . 16 . 7151–8 . 2005 . 16103065 . 10.1158/0008-5472.CAN-05-1400 . 1681523 .
• Saeki N, Kim DH, Usui T, etal . GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling . Oncogene . 26 . 45 . 6488–98 . 2007 . 17471240 . 10.1038/sj.onc.1210475 . 31245781 .

Notes and References

1. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH . The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 . Proc Natl Acad Sci U S A . 88 . 10 . 4367–71 . June 1991 . 2034676 . 51660 . 10.1073/pnas.88.10.4367 . 1991PNAS...88.4367B . free .
2. McGuire EA, Davis AR, Korsmeyer SJ . T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells . Blood . 77 . 3 . 599–606 . March 1991 . 1703797 . 10.1182/blood.V77.3.599.599. free .
3. Web site: Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1).
4. Ono . Y . Fukuhara N . Yoshie O . December 1998 . TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3 . Mol. Cell. Biol. . 18 . 12 . 6939–50 . 0270-7306. 9819382 . 109277 . 10.1128/MCB.18.12.6939 .
5. Ono . Y . Fukuhara N . Yoshie O . February 1997 . Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL . J. Biol. Chem. . 272 . 7 . 4576–81 . 0021-9258. 9020185 . 10.1074/jbc.272.7.4576 . free .
6. Valge-Archer . V E . Osada H . Warren A J . Forster A . Li J . Baer R . Rabbitts T H . August 1994 . The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells . . 91 . 18 . 8617–21 . 0027-8424. 8078932 . 1994PNAS...91.8617V . 10.1073/pnas.91.18.8617 . 44657 . free .
7. Wadman . I . Li J . Bash R O . Forster A . Osada H . Rabbitts T H . Baer R . October 1994 . Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia . EMBO J. . 13 . 20 . 4831–9 . 0261-4189. 7957052 . 395422 . 10.1002/j.1460-2075.1994.tb06809.x .