LLGL1 explained

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.^{[1] [2]}

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[3]

Further reading

• Campbell HD, Fountain S, Young IG, etal . Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. . Genomics . 42 . 1 . 46–54 . 1997 . 9177775 . 10.1006/geno.1997.4709 .
• Ludford-Menting MJ, Thomas SJ, Crimeen B, etal . A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. . J. Biol. Chem. . 277 . 6 . 4477–84 . 2002 . 11714708 . 10.1074/jbc.M108479200 . free .
• Bi W, Yan J, Stankiewicz P, etal . Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse . Genome Res. . 12 . 5 . 713–28 . 2002 . 11997338 . 10.1101/gr.73702 . 186594 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yamanaka T, Horikoshi Y, Sugiyama Y, etal . Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity . Curr. Biol. . 13 . 9 . 734–43 . 2004 . 12725730 . 10.1016/S0960-9822(03)00244-6 . 18570360 . free .
• Grifoni D, Garoia F, Schimanski CC, etal . The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo . Oncogene . 23 . 53 . 8688–94 . 2004 . 15467749 . 10.1038/sj.onc.1208023 . 23322807 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Schimanski CC, Schmitz G, Kashyap A, etal . Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer . Oncogene . 24 . 19 . 3100–9 . 2005 . 15735678 . 10.1038/sj.onc.1208520 . free .
• Kuphal S, Wallner S, Schimanski CC, etal . Expression of Hugl-1 is strongly reduced in malignant melanoma . Oncogene . 25 . 1 . 103–10 . 2006 . 16170365 . 10.1038/sj.onc.1209008 . 9808205 .
• Grifoni D, Garoia F, Bellosta P, etal . aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia . Oncogene . 26 . 40 . 5960–5 . 2007 . 17369850 . 10.1038/sj.onc.1210389 . 12965688 .

Notes and References

1. Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF . A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain . Oncogene . 11 . 2 . 291–301 . Aug 1995 . 7542763 . etal.
2. Koyama K, Fukushima Y, Inazawa J, Tomotsune D, Takahashi N, Nakamura Y . The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2 . Cytogenet Cell Genet . 72 . 1 . 78–82 . Mar 1996 . 8565641 . 10.1159/000134167 .
3. Web site: Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila).