LIPH (gene) explained

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.^{[1] [2] [3]}

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.

Further reading

• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wen XY . Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans . Hum. Mol. Genet. . 12 . 10 . 1131–43 . 2004 . 12719377 . 10.1093/hmg/ddg124 . vanc. Hegele RA . Wang J . 3 . Wang . DY . Cheung . J . Wilson . M . Yahyapour . M . Bai . Y . Zhuang . L . free .
• Hiramatsu T . Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta . J. Biol. Chem. . 278 . 49 . 49438–47 . 2004 . 12963729 . 10.1074/jbc.M213018200 . vanc. Sonoda H . Takanezawa Y . 3 . Morikawa . R . Ishida . M . Kasahara . K . Sanai . Y . Taguchi . R . Aoki . J . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Aslam M . A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3 . J. Med. Genet. . 41 . 11 . 849–52 . 2005 . 15520410 . 10.1136/jmg.2004.019729 . 1735610 . vanc. Chahrour MH . Razzaq A . 3 . Haque . S . Yan . K . Leal . SM . Ahmad . W .
• Kazantseva A . Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH . Science . 314 . 5801 . 982–5 . 2006 . 17095700 . 10.1126/science.1133276 . vanc. Goltsov A . Zinchenko R . 3 . Grigorenko . A. P. . Abrukova . A. V. . Moliaka . Y. K. . Kirillov . A. G. . Guo . Z. . Lyle . S. . 2006Sci...314..982K . 17395376 .
• Ali G . A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis . Hum. Genet. . 121 . 3–4 . 319–25 . 2007 . 17333281 . 10.1007/s00439-007-0344-0 . vanc. Chishti MS . Raza SI . 3 . John . Peter . Ahmad . Wasim . 9640640 .

Notes and References

1. Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ . Lipase H, a new member of the triglyceride lipase family synthesized by the intestine . Genomics . 80 . 3 . 268–73 . Sep 2002 . 12213196 . 10.1006/geno.2002.6837 .
2. Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H . A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid . J Biol Chem . 277 . 37 . 34254–63 . Sep 2002 . 12063250 . 10.1074/jbc.M201659200 . free .
3. Web site: Entrez Gene: LIPH lipase, member H.