LIN7B explained

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^{[1] [2]}

Interactions

LIN7B has been shown to interact with:

• ACCN3,^[3]
• GRIN2B,
• KCNJ12^{[4] [5]} and
• KCNJ4.^[6]

Further reading

• Butz S, Okamoto M, Südhof TC . A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. . Cell . 94 . 6 . 773–82 . 1998 . 9753324 . 10.1016/S0092-8674(00)81736-5 . 12465062 . free .
• Olsen O, Liu H, Wade JB, Merot J, Welling PA . Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. . Am. J. Physiol., Cell Physiol. . 282 . 1 . C183–95 . 2002 . 11742811 . 10.1152/ajpcell.00249.2001 .
• Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C . Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. . J. Neurosci. . 22 . 15 . 6426–36 . 2002 . 12151522 . 6758172 . 10.1523/JNEUROSCI.22-15-06426.2002 .
• Hori K, Konno D, Maruoka H, Sobue K . MALS is a binding partner of IRSp53 at cell-cell contacts. . FEBS Lett. . 554 . 1–2 . 30–4 . 2003 . 14596909 . 10.1016/S0014-5793(03)01074-3 . 30329043 . free .
• Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. . J. Biol. Chem. . 279 . 18 . 19051–63 . 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. . J. Biol. Chem. . 279 . 21 . 22331–46 . 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
• Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ . PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. . J. Biol. Chem. . 279 . 45 . 46962–8 . 2004 . 15317815 . 10.1074/jbc.M405874200 . free .
• Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW . Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. . J. Biol. Chem. . 280 . 47 . 39653–64 . 2006 . 16192269 . 10.1074/jbc.M510187200 . free .
• Kawai S, Fukuda C, Mukai T, Murata K . MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase. . J. Biol. Chem. . 280 . 47 . 39200–7 . 2006 . 16192277 . 10.1074/jbc.M506426200 . free .
• Li Z, Benard O, Margolskee RF . Ggamma13 interacts with PDZ domain-containing proteins. . J. Biol. Chem. . 281 . 16 . 11066–73 . 2006 . 16473877 . 10.1074/jbc.M600113200 . free .
• Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K . Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. . Neurosci. Res. . 56 . 4 . 347–55 . 2007 . 16979770 . 10.1016/j.neures.2006.08.003 . 45834664 .

Notes and References

1. Jo K, Derin R, Li M, Bredt DS . Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex . J Neurosci . 19 . 11 . 4189–99 . Jun 1999 . 10341223 . 6782594. 10.1523/JNEUROSCI.19-11-04189.1999. free .
2. Web site: Entrez Gene: LIN7B lin-7 homolog B (C. elegans).
3. Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ . PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current . J. Biol. Chem. . 279 . 45 . 46962–8 . Nov 2004 . 15317815 . 10.1074/jbc.M405874200 . free .
4. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .
5. Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA . A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels . J. Biol. Chem. . 279 . 18 . 19051–63 . Apr 2004 . 14960569 . 10.1074/jbc.M400284200 . free .
6. Olsen O, Liu H, Wade JB, Merot J, Welling PA . Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex . Am. J. Physiol., Cell Physiol. . 282 . 1 . C183-95 . Jan 2002 . 11742811 . 10.1152/ajpcell.00249.2001 .