LIM domain-binding protein family explained

Symbol:	LIM_bind
LIM-domain binding protein
Pfam:	PF01803
Interpro:	IPR002691
Scop:	1j2o

In molecular biology, the LIM domain-binding protein family is a family of proteins which binds to the LIM domain of LIM (LIN-11, Isl-1 and MEC-3) homeodomain proteins which are transcriptional regulators of development.

Examples

Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with ISL1 in early motor neuron differentiation and has a suggested role in the ISL1 dependent development of motor neurons.^[1] It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development.^[2] The Drosophila melanogaster protein Chip is required for segmentation and activity of a remote wing margin enhancer.^[3] Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development.^[3] It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.^[3]

Notes and References

1. Jurata LW, Kenny DA, Gill GN . Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development . Proc. Natl. Acad. Sci. U.S.A. . 93 . 21 . 11693–8 . October 1996 . 8876198 . 38120 . 10.1073/pnas.93.21.11693. 1996PNAS...9311693J . free .
2. Bach I, Carriere C, Ostendorff HP, Andersen B, Rosenfeld MG . A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins . Genes Dev. . 11 . 11 . 1370–80 . June 1997 . 9192866 . 10.1101/gad.11.11.1370. free .
3. Morcillo P, Rosen C, Baylies MK, Dorsett D . Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila . Genes Dev. . 11 . 20 . 2729–40 . October 1997 . 9334334 . 316608 . 10.1101/gad.11.20.2729.