LIMS2 explained

LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene.^[1]

Function

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

Further reading

• Zhang Y, Chen K, Guo L, Wu C . Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration . J. Biol. Chem. . 277 . 41 . 38328–38 . 2002 . 12167643 . 10.1074/jbc.M205576200 . free .
• Kim SK, Jang HR, Kim JH, Noh SM, Song KS, Kim MR, Kim SY, Yeom YI, Kim NS, Yoo HS, Kim YS . The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration . Biochem. Biophys. Res. Commun. . 349 . 3 . 1032–40 . 2006 . 16959213 . 10.1016/j.bbrc.2006.08.128 .
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M . New genetic associations detected in a host response study to hepatitis B vaccine . Genes Immun. . 11 . 3 . 232–8 . 2010 . 20237496 . 10.1038/gene.2010.1 . free .
• Yuan Y, Dong HP, Nymoen DA, Nesland JM, Wu C, Davidson B . PINCH-2 expression in cancers involving serosal effusions using quantitative PCR . Cytopathology . 22 . 1 . 22–9 . 2011 . 20500520 . 3225403 . 10.1111/j.1365-2303.2010.00757.x .
• Park CH, Rha SY, Ahn JB, Shin SJ, Kwon WS, Kim TS, An S, Kim NK, Yang WI, Chung HC . PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity . Int. J. Cancer . 136 . 10 . 2273–83 . 2015 . 25346044 . 10.1002/ijc.29273 . 2850271 . free .
• Chardon JW, Smith AC, Woulfe J, Pena E, Rakhra K, Dennie C, Beaulieu C, Huang L, Schwartzentruber J, Hawkins C, Harms MB, Dojeiji S, Zhang M, Majewski J, Bulman DE, Boycott KM, Dyment DA . LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues . Clin. Genet. . 88 . 6 . 558–64 . 2015 . 25589244 . 10.1111/cge.12561 . 23714774 .

Notes and References

1. Web site: Entrez Gene: LIM zinc finger domain containing 2. 2017-11-06.