LIME1 explained

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene.^{[1] [2]}

LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells.^[3]

Further reading

• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Hur EM . LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation . J. Exp. Med. . 198 . 10 . 1463–73 . 2004 . 14610044 . 10.1084/jem.20030232 . 2194117 . vanc. Son M . Lee OH . 3 . Choi . Y. B. . Park . C. . Lee . H. . Yun . Y. .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Suzuki Y . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . vanc. Yamashita R . Shirota M . 3 . Sakakibara . Y . Chiba . J . Mizushima-Sugano . J . Nakai . K . Sugano . S .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wan D . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . vanc. Gong Y . Qin W . 3 . Zhang . P . Li . J . Wei . L . Zhou . X . Li . H . Qiu . X . 2004PNAS..10115724W . free .
• Tedoldi S . Transmembrane adaptor molecules: a new category of lymphoid-cell markers . Blood . 107 . 1 . 213–21 . 2006 . 16160011 . 10.1182/blood-2005-06-2273 . vanc. Paterson JC . Hansmann ML . 3 . Natkunam . Y . Rüdiger . T . Angelisova . P . Du . MQ . Roberton . H . Roncador . G . 340034 . free .
• Ahn E, Lee H, Yun Y . LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation . Blood . 107 . 4 . 1521–7 . 2006 . 16249387 . 10.1182/blood-2005-05-1859 . 1139121 . free .

Notes and References

1. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc Natl Acad Sci U S A . 99 . 26 . 16899–903 . Dec 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
2. Web site: Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1.
3. Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V . LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling . J Exp Med . 198 . 10 . 1453–62 . November 2003 . 14610046 . 2194115 . 10.1084/jem.20031484 .