LILRB3 explained

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.^{[1] [2] [3]}

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

See also

• Cluster of differentiation

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Sloane DE, Tedla N, Awoniyi M, etal . Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. . Blood . 104 . 9 . 2832–9 . 2004 . 15242876 . 10.1182/blood-2004-01-0268 .
• Tedla N, Bandeira-Melo C, Tassinari P, etal . Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 3 . 1174–9 . 2003 . 12529506 . 10.1073/pnas.0337567100 . 298746 . 2003PNAS..100.1174T . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wende H, Volz A, Ziegler A . Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. . Immunogenetics . 51 . 8–9 . 703–13 . 2000 . 10941842 . 10.1007/s002510000187 . 20719684 .
• Borges L, Hsu ML, Fanger N, etal . A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. . J. Immunol. . 159 . 11 . 5192–6 . 1998 . 10.4049/jimmunol.159.11.5192 . 9548455 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Cella M, Döhring C, Samaridis J, etal . A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. . J. Exp. Med. . 185 . 10 . 1743–51 . 1997 . 9151699 . 10.1084/jem.185.10.1743 . 2196312 .
• Samaridis J, Colonna M . Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. . Eur. J. Immunol. . 27 . 3 . 660–5 . 1997 . 9079806 . 10.1002/eji.1830270313 . 2212182 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Arm JP, Nwankwo C, Austen KF . Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor . J Immunol . 159 . 5 . 2342–9 . Sep 1997 . 10.4049/jimmunol.159.5.2342 . 9278324 .
2. Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M . A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells . J Exp Med . 186 . 11 . 1809–18 . Dec 1997 . 9382880 . 2199153 . 10.1084/jem.186.11.1809 .
3. Web site: Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3.
4. Web site: Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3.