LGSN explained
Lengsin is a protein that in humans is encoded by the LGSN gene.
Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[1] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.
Further reading
- Wyatt K, White HE, Wang L, Bateman OA, Slingsby C, Orlova EV, Wistow G . Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens . Structure . London, England . 14 . 12 . 1823–34 . December 2006 . 17161372 . 1868402 . 10.1016/j.str.2006.10.008 .
External links
Notes and References
- Wyatt K, Gao C, Tsai JY, Fariss RN, Ray S, Wistow G . A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens . The Journal of Biological Chemistry . 283 . 10 . 6607–15 . March 2008 . 18178558 . 10.1074/jbc.M709144200 . 2911820 . free .
